Potential role of glucosamine-phosphate N-acetyltransferase 1 in the development of lung adenocarcinoma.

Glucosamine-phosphate N-acetyltransferase 1 (GNPNAT1) is a key enzyme associated with glucose metabolism and uridine diphosphate-N-acetylglucosamine biosynthesis. Abnormal expression might be associated with carcinogenesis. We analyzed multiple lung adenocarcinoma (LUAD) gene expression databases and verified higher expression in LUAD tumor tissues than in normal tissues. Moreover, we analyzed the survival relationship between LUAD patients' clinical status and expression, and found higher expression in LUAD patients with unfavorable prognosis. We built gene co-expression networks and further annotated the co-expressed genes' Gene Ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and various associated regulatory factors. These co-expression genes' functional networks mainly participate in chromosome segregation, RNA metabolic process, and RNA transport. We analyzed genetic alterations and co-occurrence networks, and the functional networks of these genes showed that participates in multiple steps of cell cycle transition and in the development of some cancers. We assessed the correlation between expression and cancer immune infiltrates and showed that expression is correlated with several immune cells, chemokines, and immunomodulators in LUAD. We found that correlates with LUAD development and prognosis, laying a foundation for further research, especially in immunotherapy.