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十二指肠、壶腹区、空肠和回肠的神经内分泌肿瘤。

Neuroendocrine neoplasms of the duodenum, ampullary region, jejunum and ileum.

机构信息

1st Pathology Division, Department of Pathology and Laboratory Medicine Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Unit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.

出版信息

Pathologica. 2021 Feb;113(1):12-18. doi: 10.32074/1591-951X-228.

DOI:10.32074/1591-951X-228
PMID:33686306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8138699/
Abstract

Neuroendocrine neoplasms of the small intestine are some of the most frequently occurring along the gastrointestinal tract, even though their incidence is extremely variable according to specific sites. Jejunal-ileal neuroendocrine neoplasms account for about 27% of gastrointestinal NETs making them the second most frequent NET type. The aim of this review is to classify all tumors following the WHO 2019 classification and to describe their pathologic differences and peculiarities.

摘要

小肠的神经内分泌肿瘤是胃肠道中最常见的肿瘤之一,尽管其发病率根据特定部位而有很大差异。空肠-回肠神经内分泌肿瘤占胃肠道 NET 的 27%左右,是第二常见的 NET 类型。本文旨在根据 2019 年 WHO 分类对所有肿瘤进行分类,并描述其病理差异和特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/d01f0af8387b/pathol-2021-01-12-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/860fc4e796c9/pathol-2021-01-12-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/2ad8b02b7842/pathol-2021-01-12-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/d01f0af8387b/pathol-2021-01-12-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/860fc4e796c9/pathol-2021-01-12-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/2ad8b02b7842/pathol-2021-01-12-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/430a/8138699/d01f0af8387b/pathol-2021-01-12-g003.jpg

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Hum Pathol. 2020 Sep;103:72-82. doi: 10.1016/j.humpath.2020.07.010. Epub 2020 Jul 12.
2
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3
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