Department of Nephrology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, No.15 Jiefang Road, Fancheng District, Xiangyang, Hubei, China.
Geriatrics Department, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, No.15 Jiefang Road, Fancheng District, Xiangyang, Hubei, China.
Int Urol Nephrol. 2021 Dec;53(12):2627-2633. doi: 10.1007/s11255-021-02801-1. Epub 2021 Mar 8.
The purpose of our study was to retrospectively analyze the characteristic of death from kidney diseases among cancer patients and to screen the risk factors associated with nephrotic death using data from the surveillance, epidemiology, and end results (SEER) database.
The information on cancer patients dying of kidney diseases was retrieved from the SEER database. Standardized mortality ratios (SMRs) were calculated using the US general population as reference. Univariate and multivariate Cox regression analyses were conducted to screen potential risk factors of death from kidney diseases.
Data of 7,167,808 patients diagnosed with malignant tumors between 2000 and 2016 were collected. Of these, 25,903 patients died of kidney diseases. Compared to the general population, cancer patients were at an elevated risk of nephrotic death with an SMR of 3.17, and this risk continues to increase in recent years. The majority of deaths from kidney diseases occur in patients > 45-year-old diagnosed with cancer of prostate, colorectum, and breast. Additionally, cancer patients with diagnosis in recent years, older age at diagnosis, black race, higher grade, and poorer disease stage were more likely to die of kidney diseases are at higher risk of nephrotic death compared to other cancer survivors.
The risk of death from kidney diseases is increasing among cancer survivors recently. Nephrologists should be actively involved in certain facets of cancer treatment, and provide effective nephrology care, especially for elderly patients with black race, higher grade, and poorer disease stage.
本研究旨在回顾性分析癌症患者因肾脏疾病死亡的特征，并利用监测、流行病学和最终结果（SEER）数据库筛选与肾病死亡相关的风险因素。
从 SEER 数据库中检索因肾脏疾病死亡的癌症患者信息。使用美国一般人群作为参考计算标准化死亡率（SMR）。采用单因素和多因素 Cox 回归分析筛选肾病死亡的潜在风险因素。
共收集了 2000 年至 2016 年间诊断为恶性肿瘤的 7167808 例患者的数据，其中 25903 例死于肾脏疾病。与一般人群相比，癌症患者患肾病的风险升高，SMR 为 3.17，且近年来这一风险持续增加。大多数死于肾脏疾病的患者年龄均>45 岁，且患有前列腺癌、结直肠癌和乳腺癌。此外，与其他癌症幸存者相比，近年来诊断、年龄较大、黑种人、更高分级和较差疾病分期的癌症患者更易死于肾脏疾病，发生肾病死亡的风险更高。
癌症幸存者因肾脏疾病死亡的风险最近在增加。肾脏病医生应该积极参与癌症治疗的某些方面，并提供有效的肾脏科护理，尤其是针对黑种人、较高分级和较差疾病分期的老年患者。
