Physical Medicine and Rehabilitation, Selcuk University Faculty of Medicine, Konya, Turkey.
Biostatistics, Selcuk University Faculty of Medicine, Konya, Turkey.
Int J Clin Pract. 2021 Jun;75(6):e14135. doi: 10.1111/ijcp.14135. Epub 2021 Mar 14.
To investigate the frequency of fatigue and musculoskeletal symptoms and their correlation with laboratory data in patients with COVID-19.
This study included 80 patients hospitalised and treated for COVID-19 in the infectious diseases clinic between March 2020 and May 2020. Data analysis was performed retrospectively from the hospital medical charts. Demographic data, clinical symptoms, and laboratory findings were noted. Clinical symptoms and correlations with laboratory results were assessed. Besides, an analysis of patients with and without chronic disease was performed for clinical symptoms and laboratory findings.
The frequencies of myalgia and fatigue were 46.1% and 50%, respectively. In the laboratory data, there was a significant increase in creatinine kinase (CK) level and lymphocyte count in the patients with myalgia symptoms (P < .05). There were no other significant results in the laboratory data. Of the patients with chronic disease, it has been shown that hemoglobin levels were significantly decreased (P < .05), while D-dimer was markedly increased (P < .05).
The laboratory findings of COVID-19-related myalgia suggested that patients might have a risk of progressive muscle injury. Therefore, these patients should also be followed up in terms of the myopathic process.
研究 COVID-19 患者疲劳和肌肉骨骼症状的频率及其与实验室数据的相关性。
本研究纳入了 2020 年 3 月至 5 月期间在传染病诊所住院和治疗 COVID-19 的 80 名患者。从医院病历中进行回顾性数据分析。记录人口统计学数据、临床症状和实验室发现。评估临床症状及其与实验室结果的相关性。此外，还对有和没有慢性病的患者进行了临床症状和实验室发现的分析。
肌肉疼痛和疲劳的发生率分别为 46.1%和 50%。在实验室数据中，有肌肉疼痛症状的患者肌酸激酶（CK）水平和淋巴细胞计数显著升高（P<.05）。实验室数据中没有其他显著结果。对于有慢性病的患者，血红蛋白水平显著降低（P<.05），而 D-二聚体明显升高（P<.05）。
COVID-19 相关肌肉疼痛的实验室发现表明患者可能有肌肉损伤进展的风险。因此，这些患者也应在肌病过程方面进行随访。
