生物流体中呋氟尿嘧啶的葡萄糖醛酸苷测定
GLC determination for ftorafur in biological fluids.
作者信息
Hills E B, Godefroi V C, O'Leary I A, Burke M, Andrzejewski D, Brukwinski W, Horwitz J P
出版信息
J Pharm Sci. 1977 Oct;66(10):1497-9. doi: 10.1002/jps.2600661043.
A GLC analysis for free ftorafur was developed to follow in drug disposition in body fluids of patients. The free drug was extracted from aqueous biological samples with chloroform, derivatized by methylation, and chromatographed on 1% HI-EFF 8BP using flame-ionization detection. The analysis is sensitive (0.25 microgram/ml of plasma) and specific for the intact molecule, and it does not interfere with subsequent fluorouracil analysis of the same sample.
已开发出一种用于测定游离替加氟的气相色谱分析方法，以追踪患者体液中的药物处置情况。游离药物用氯仿从水性生物样品中萃取，通过甲基化进行衍生化，然后在1% HI-EFF 8BP上进行色谱分析，并使用火焰离子化检测。该分析方法灵敏度高（血浆中为0.25微克/毫升），对完整分子具有特异性，且不干扰同一样品随后的氟尿嘧啶分析。
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