Department of Dermatology, Ministry of Health Ankara City Hospital, Ankara, Turkey.
Turk J Pediatr. 2021;63(1):126-135. doi: 10.24953/turkjped.2021.01.015.
Lichen sclerosus (LS) is a chronic disease of the skin, for which the pathogenesis is not known. It can lead to various changes of the skin and the genital area, potentially leading to both functional as well as cosmetic problems for the patient, thus disrupting the quality of life. In this study; the purpose was to review the clinical characteristics and the treatments of the 15 pediatric patients under the age of 18 followed up in our out-patient clinic with a diagnosis of LS and to compare the findings with literature data.
Between 2011 and 2017, the files of 15 patients diagnosed clinically and/or histologically with LS in our clinic were retrospectively examined. The demographic characteristics, clinic and laboratory findings, treatment options of the patients are reported.
Of the patients included in the study 14 were girls and one was a boy. The average age was 11.6 years (5-17 years), the average age for the initial disease was 7.8 years (2-13 years). The average duration of the disease at the diagnosis was 3.9 years. The most common form was genital vulvar type (8/14 girls) without anal and cutaneous involvement, and each of them suffered from itching. One of the cases had genital LS as well as extragenital morphea lesions. Two of the 15 patients were ANA positive. The other antibodies were negative. In two cases with extragenital involvement, lesions were widespread and they were in blachkoid form.
LS is a chronic disease that progresses with recurrences and regressions. In our study, the most common LS type was genital type (60%). There was extragenital involvement in 6 patients (40%). Extragenital involvement was the most common on the trunk. Diagnosis, treatment and follow-up during childhood is highly important to prevent any possible future anatomical or psychological damage and genital malignancies.
硬化性苔藓（LS）是一种皮肤慢性疾病，其发病机制尚不清楚。它会导致皮肤和生殖器区域的各种变化，可能会给患者带来功能和美容问题，从而破坏其生活质量。本研究旨在回顾在我们的门诊就诊的 15 名 18 岁以下儿童患者的临床特征和治疗方法，并与文献数据进行比较。
2011 年至 2017 年，对我院临床和/或组织学诊断为 LS 的 15 例患者的病历进行回顾性分析。报告了患者的人口统计学特征、临床和实验室检查结果、治疗选择。
研究纳入的 15 例患者中，14 例为女孩，1 例为男孩。平均年龄为 11.6 岁（5-17 岁），首发疾病平均年龄为 7.8 岁（2-13 岁）。诊断时疾病的平均病程为 3.9 年。最常见的形式是生殖器外阴型（14 例女孩中的 8 例），无肛门和皮肤受累，且均有瘙痒。一例患者既有生殖器 LS，又有外阴硬皮病样病变。15 例患者中有 2 例抗核抗体阳性，其他抗体均为阴性。在 2 例有外阴受累的患者中，病变广泛，呈黑色萎缩性。
LS 是一种慢性疾病，会反复发作和缓解。在我们的研究中，最常见的 LS 类型是生殖器型（60%）。有 6 例（40%）有外阴外受累。外阴外受累最常见于躯干。在儿童时期进行诊断、治疗和随访对于防止任何可能的未来解剖学或心理损伤以及生殖器恶性肿瘤非常重要。
