[小儿硬化性苔藓：11例女童病例系列]

[Pediatric genital lichen sclerosus: a case series of 11 girls].

作者信息

Aróstegui Aguilar Jorge, Loidi Leire, Hiltun Ingrid, Larrea Mónica, Cascante Lourdes, Yanguas Juan Ignacio

机构信息

Servicio de Dermatología. Hospital Universitario de Navarra. Servicio Navarro de Sa-lud-Osasunbidea. Pamplona. España..

出版信息

An Sist Sanit Navar. 2022 Nov 18;45(3):e1014. doi: 10.23938/ASSN.1014.

DOI:10.23938/ASSN.1014

PMID:36408571

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10065031/

Abstract

BACKGROUND

Genital lichen sclerosus decreases the quality of life of women; 10-15% of cases occur in prepubertal girls.

METHODS

Retrospective and descriptive study on the characteristics of girls diagnosed with genital lichen sclerosus at the Hospital Universitario de Navarra (Pamplona, Spain) between 2019 and 2022.

RESULTS

Eleven girls aged between 4 and 14 year-old were diagnosed. Frequently, diagnostic delays were up to two years after the appearance of the lesions; the girl with a four-year delay showed a significant vulvar architectural alteration. All cases showed the typical sclerotic lesions on the genital area, and two of them also on the back. While six patients were asymptomatic, the rest reported pruritus and/or pain. Treatment with high/very high potency topical cortico-steroids achieved a good partial response, without complete remission of the lesions.

CONCLUSION

Early diagnosis of genital lichen sclerosus is key to start early treatment, avoiding ireversible genital structural alteration.

摘要

背景

外阴硬化性苔藓会降低女性的生活质量；10% - 15%的病例发生在青春期前女孩。

方法

对2019年至2022年期间在西班牙潘普洛纳纳瓦拉大学医院被诊断为外阴硬化性苔藓的女孩的特征进行回顾性和描述性研究。

结果

共诊断出11名年龄在4至14岁之间的女孩。诊断通常在病变出现后延迟长达两年；延迟四年的女孩出现了明显的外阴结构改变。所有病例在生殖器区域均出现典型的硬化性病变，其中两例背部也有病变。6例患者无症状，其余患者报告有瘙痒和/或疼痛。使用高效/超强效外用皮质类固醇治疗取得了较好的部分缓解，但病变未完全消退。