Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, Fujian, China.
Aging (Albany NY). 2021 Mar 3;13(6):8155-8176. doi: 10.18632/aging.202625.
FAM72A-D promote the self-renewal of neural progenitor cells. There is accumulating evidence that FAM72 promotes tumorigenicity. However, its effects in lung adenocarcinoma (LUAD) have not been determined. Thus, we evaluated the prognostic value of in LUAD using bioinformatics approaches. In particular, we evaluated the relationship between FAM72 and LUAD using a wide range of databases and analysis tools, including TCGA, GEO, GEPIA, Metascape, cBioPortal, and MethSurv. Compared with its expression in normal lung tissues, FAM72 expression was significantly increased in LUAD tissues. A univariate Cox analysis showed that high FAM72 expression levels were correlated with a poor OS in LUAD. Additionally, FAM72 expression was independently associated with OS through a multivariate Cox analysis. GO and GSEA revealed enrichment in mitotic nuclear division and cell cycle. Moreover, high FAM72 expression was associated with poor survival. An analysis of immune infiltration showed that FAM72 is correlated with immune cell infiltration. Finally, we found that the methylation level was associated with prognosis in patients with LUAD. In summary, these results indicate that FAM72 is a potential molecular marker for poor prognosis in LUAD and provide additional insight for the development of therapies and prognostic markers.
FAM72A-D 促进神经祖细胞的自我更新。越来越多的证据表明 FAM72 促进了肿瘤的发生。然而，其在肺腺癌（LUAD）中的作用尚未确定。因此，我们使用生物信息学方法评估 FAM72 在 LUAD 中的预后价值。特别是，我们使用了包括 TCGA、GEO、GEPIA、Metascape、cBioPortal 和 MethSurv 在内的广泛数据库和分析工具来评估 FAM72 与 LUAD 之间的关系。与正常肺组织中的表达相比，FAM72 在 LUAD 组织中的表达明显增加。单因素 Cox 分析显示，高 FAM72 表达水平与 LUAD 的不良 OS 相关。此外，多因素 Cox 分析表明，FAM72 表达与 OS 独立相关。GO 和 GSEA 显示有丝分裂核分裂和细胞周期的富集。此外，高 FAM72 表达与不良预后相关。免疫浸润分析表明 FAM72 与免疫细胞浸润相关。最后，我们发现 LUAD 患者的甲基化水平与预后相关。总之，这些结果表明 FAM72 是 LUAD 不良预后的潜在分子标志物，并为治疗和预后标志物的开发提供了额外的见解。
