Chasnoff I J, Chisum G M, Kaplan W E
Department of Pediatrics, Northwestern University Medical School, Northwestern Memorial Hospital, Chicago, Illinois 60611.
Teratology. 1988 Mar;37(3):201-4. doi: 10.1002/tera.1420370304.
A specific fetal disruption syndrome associated with maternal cocaine use has not as yet been documented. In the first 23 pregnancies evaluated in our program for chemically dependent women, one infant with prune belly syndrome and one infant with hypospadias were delivered to cocaine-using women. In the present study, all infants delivered in our program received a renal ultrasound at 2-3 days of life. Fifty infants born to cocaine-using women (group I) and 30 born to polydrug, noncocaine-using women (group II) were evaluated. The two groups of women were similar for age, gravidity, and race. Mean birth weight of the infants in the two groups was similar. Seven infants in group I demonstrated genitourinary tract malformations while there were no infants with such malformations in group II. It is hypothesized that the vasoconstrictive effects of cocaine could explain the abnormalities of the genitourinary tract found in the cocaine-exposed infants.
与母亲使用可卡因相关的特定胎儿发育异常综合征尚未有文献记载。在我们为药物成瘾女性设立的项目中评估的前23例妊娠中，一名患有梅干腹综合征的婴儿和一名患有尿道下裂的婴儿由使用可卡因的女性分娩。在本研究中，我们项目中分娩的所有婴儿在出生后2至3天接受了肾脏超声检查。对50名使用可卡因女性所生的婴儿（第一组）和30名使用多种药物但不使用可卡因女性所生的婴儿（第二组）进行了评估。两组女性在年龄、妊娠次数和种族方面相似。两组婴儿的平均出生体重相似。第一组中有7名婴儿表现出泌尿生殖道畸形，而第二组中没有此类畸形的婴儿。据推测，可卡因的血管收缩作用可以解释在接触可卡因的婴儿中发现的泌尿生殖道异常。
