Department of Infectious Diseases and Epidemiology, Dermatology and Venereology, Virology and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Department of Medical Biochemistry, Virology and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Vector Borne Zoonotic Dis. 2021 Apr;21(4):301-303. doi: 10.1089/vbz.2020.2715. Epub 2021 Feb 2.
Although in Ukraine the incidence of Lyme borreliosis (LB) has been surging up over the past decades, seroepidemiologic data are not available to date. The objective of this report was to perform preliminary serological survey of hospitalized population for LB. Sera were collected from 203 patients of a hospital located in Western Ukraine. Most patients showed clinical signs that were compatible with LB such as arthritis ( = 29), neurological signs ( = 35), and erythema migrans (EM)-like lesions ( = 60) or unrelated to LB ( = 79). The specimens were tested by enzyme-linked immunosorbent assay and Western blot for anti- antibodies. LB was confirmed in 8.6%, 34.5%, and 50% of the patients, who exhibited neurological signs, arthritis, or EM-like lesions, respectively. Anti- antibodies were also detected in 6.3% of the patients with pulmonary tuberculosis. This study provides the first preliminary data on the seroprevalence of LB in Ukraine. Future studies are warranted to investigate more subsets of the Ukrainian population for this emerging tick-borne disease.
尽管过去几十年来乌克兰的莱姆病（LB）发病率一直在上升，但目前还没有血清流行病学数据。本报告的目的是对住院患者进行 LB 的初步血清学调查。从乌克兰西部一家医院的 203 名患者中采集了血清。大多数患者表现出与 LB 相符的临床症状，如关节炎（ = 29）、神经系统症状（ = 35）、游走性红斑样病变（EM）（ = 60）或与 LB 无关（ = 79）。通过酶联免疫吸附试验和 Western blot 对标本进行了抗抗体检测。分别有 8.6%、34.5%和 50%的神经系统症状、关节炎或 EM 样病变患者被确诊为 LB。在患有肺结核的患者中也检测到了抗抗体。本研究提供了乌克兰 LB 血清流行率的首批初步数据。需要进一步研究更多乌克兰人群亚组，以调查这种新出现的蜱传疾病。
