Menopause Research Group, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Family Planning and Reproductive Health Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Climacteric. 2021 Aug;24(4):394-400. doi: 10.1080/13697137.2021.1889499. Epub 2021 Mar 10.
The aim of this study was to determine the prevalence and associated factors of mild cognitive impairment (MCI) and subtypes, amnestic MCI (aMCI) and non-amnestic MCI (naMCI), in women with surgical menopause.
We obtained the database containing information for 200 women with surgical menopause from our previous study. The Montreal Cognitive Assessment - total score, the Montreal Cognitive Assessment - memory index score (MoCA-MIS) and their age, years since menopause, education, medical and surgical history, hormone therapy use, exercise, sleep duration, alcohol use, smoking and family history of dementia were obtained. All participants without the MoCA-MIS were excluded.
The average age of the 164 participants was 56.3 ± 6.9 years. The prevalence of MCI, aMCI and naMCI was 43.3%, 9.8% and 33.5%, respectively. The duration of education reduced MCI for 93% (95% confidence interval 0.03-0.20) of the women. In late postmenopause, hormone therapy >10 years showed 47% lower prevalence of MCI (age-adjusted odds ratio = 0.53, 95% confidence interval 0.22-1.28). Finally, length of education was the only independent factor associated with MCI and its subtypes.
We found a high prevalence of MCI and the non-amnestic subtype in women with surgical menopause. Further study is needed to clarify the long-term effects of surgical menopause on cognitive function.
本研究旨在确定手术绝经女性中轻度认知障碍（MCI）及其亚型（遗忘型 MCI[aMCI]和非遗忘型 MCI[naMCI]）的患病率及其相关因素。
我们从之前的研究中获取了包含 200 名手术绝经女性信息的数据库。使用蒙特利尔认知评估-总分、蒙特利尔认知评估-记忆指数评分（MoCA-MIS）及其年龄、绝经年限、教育程度、医疗和手术史、激素治疗使用情况、运动、睡眠时间、饮酒量、吸烟情况和痴呆家族史进行评估。所有 MoCA-MIS 评分缺失的参与者均被排除。
164 名参与者的平均年龄为 56.3±6.9 岁。MCI、aMCI 和 naMCI 的患病率分别为 43.3%、9.8%和 33.5%。教育年限减少了 93%（95%置信区间 0.03-0.20）女性的 MCI 发病风险。在绝经后期，激素治疗>10 年可使 MCI 的患病率降低 47%（年龄校正比值比=0.53，95%置信区间 0.22-1.28）。最后，教育年限是与 MCI 及其亚型相关的唯一独立因素。
我们发现手术绝经女性中 MCI 及非遗忘型亚型的患病率较高。需要进一步研究以阐明手术绝经对认知功能的长期影响。
