Department of Pediatrics, NYU Langone Medical Center, New York, New York.
Maimonides Medical Center, Brooklyn, New York.
JAMA Netw Open. 2021 Mar 1;4(3):e212816. doi: 10.1001/jamanetworkopen.2021.2816.
Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence in the United States are still emerging.
To elucidate SARS-CoV-2 seroprevalence and symptom onset in a culturally linked community across 5 states in the United States.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study included adults (aged ≥18 years) recruited from the orthodox Jewish community across 5 states (California, Connecticut, Michigan, New Jersey, and New York) in 3 geographically distinct areas of the United States between May 13 and July 6, 2020. Participants completed an online survey and underwent SARS-CoV-2 antibody testing.
Seroprevalence and date of symptom onset of SARS-CoV-2.
Overall, 9507 adults (mean [SD] age, 39.6 [15.0] years; 3777 [39.7%] women) completed the SARS-CoV-2 survey, of whom 6665 (70.1%) had immunoglobin G anti-SARS-CoV-2 antibody levels assessed. A high seroprevalence of SARS-CoV-2 antibodies was observed across all communities, with the highest proportion of positive testing observed in New Jersey (1080 of 3323 [32.5%]) and New York (671 of 2196 [30.6%]). Most individuals with a positive SARS-CoV-2 immunoglobin G antibody test reported a date of symptom-onset between March 9 and March 31, 2020 (California: 135 of 154 [87.7%]; Connecticut: 32 of 34 [94.1%]; Michigan: 44 of 50 [88.0%]; New Jersey: 964 of 1168 [82.5%]; New York: 571 of 677 [84.3%]). This start date was coincident with the Jewish festival of Purim, celebrated March 9 to 10, 2020, with extensive intracommunity spread in the weeks following (mean and mode of peak symptom onset, March 20, 2020), occurring in the absence of strong general and culture-specific public health directives.
This cross-sectional study of orthodox Jewish adults across the US found that socioculturally bound communities experienced early parallel outbreaks in discrete locations, notably prior to substantive medical and governmental directives. Further research should clarify optimal national, local, community-based, and government policies to prevent outbreaks in social and cultural communities that traditionally gather for holidays, assemblies, and festivals.
美国严重急性呼吸系统综合症冠状病毒 2 （SARS-CoV-2）血清流行率的数据仍在不断出现。
阐明美国 5 个州的一个文化相关社区中 SARS-CoV-2 的血清流行率和症状出现情况。
设计、地点和参与者：这项横断面研究包括从美国 3 个地理区域的 5 个州（加利福尼亚州、康涅狄格州、密歇根州、新泽西州和纽约州）的正统犹太教社区招募的成年人（年龄≥18 岁），研究时间为 2020 年 5 月 13 日至 7 月 6 日。参与者完成了在线调查并接受了 SARS-CoV-2 抗体检测。
SARS-CoV-2 的血清流行率和症状出现日期。
总体而言，9507 名成年人（平均[标准差]年龄 39.6[15.0]岁；3777[39.7%]为女性）完成了 SARS-CoV-2 调查，其中 6665 人（70.1%）的 SARS-CoV-2 免疫球蛋白 G 抗 SARS-CoV-2 抗体水平得到了评估。所有社区的 SARS-CoV-2 抗体检测均呈高阳性率，其中新泽西州（3323 例中有 1080 例[32.5%]）和纽约州（2196 例中有 671 例[30.6%]）的阳性检测比例最高。大多数 SARS-CoV-2 免疫球蛋白 G 抗体检测呈阳性的个体报告的症状出现日期在 2020 年 3 月 9 日至 3 月 31 日之间（加利福尼亚州：154 例中有 135 例[87.7%]；康涅狄格州：34 例中有 32 例[94.1%]；密歇根州：50 例中有 44 例[88.0%]；新泽西州：1168 例中有 964 例[82.5%]；纽约州：677 例中有 571 例[84.3%]）。这个开始日期恰逢犹太教的普林节，从 2020 年 3 月 9 日至 10 日庆祝，随后的几周内发生了广泛的社区内传播（高峰症状出现的平均和模式，2020 年 3 月 20 日），这发生在没有强有力的一般和文化特定公共卫生指令的情况下。
这项针对美国正统犹太成年人的横断面研究发现，社会文化上有联系的社区在不同地点同时发生了早期的平行暴发，特别是在没有实质性的医疗和政府指令之前。进一步的研究应阐明最佳的国家、地方、社区和政府政策，以防止传统上因节日、集会和节日而聚集的社交和文化社区爆发疫情。
