Stavropol State Medical University, Ministry of Healthcare of the Russian Federation, Stavropol, Russia.
Sechenov University, Moscow, Russia.
Dokl Biochem Biophys. 2021 May;496(1):36-39. doi: 10.1134/S160767292101004X. Epub 2021 Mar 10.
Using the templates preliminarily made by 3D design and prototyping methods, defects in the lateral area of the lower jaw of sheep were created using the piezosurgical technique. The defects were replaced by plastic implants obtained by the method of layer-by-layer fusion of the FDM printing-fusing deposition modeling and fixation with titanium screws to the jaw body. In the time interval, plastic implants are replaced by titanium implants obtained by selective laser sintering (SLS) using a 3D printer. To study the processes of reparative osteogenesis, microsamples of tissues of the preimplantation zone were analyzed. As a result, signs of osteo- and fibro-osseointegration were identified. The obtained data are regarded as a prerequisite for further clinical trials of the developed protocols for the sequential replacement of jaw defects using 3D printing.
使用 3D 设计和原型制作方法初步制作的模板，使用超声骨刀技术在下颌骨的侧区创建缺陷。通过 FDM 打印-熔丝沉积建模的逐层融合方法获得塑料植入物来替代缺陷，并使用钛螺钉将其固定到颌骨体上。在时间间隔内，使用 3D 打印机通过选择性激光烧结 (SLS) 将塑料植入物替换为钛植入物。为了研究修复性骨生成过程，分析了植入前区域的组织微样本。结果，鉴定出了骨和纤维骨整合的迹象。获得的数据被认为是进一步进行使用 3D 打印顺序替换颌骨缺陷的开发方案的临床试验的前提条件。
