Siddiqi A, Duncan W J, De Silva R K, Zafar S
School of Dentistry and Health Sciences, Charles Sturt University, Orange, NSW 2800, Australia.
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Biomed Res Int. 2016;2016:6792972. doi: 10.1155/2016/6792972. Epub 2016 Dec 12.
Reports have documented titanium (Ti) hypersensitivity after dental implant treatment. Alternative materials have been suggested including zirconia (Zr) ceramics, which have shown predictable osseointegration in animal studies and appear free of immune responses. The aim of the research was to investigate the bone-to-implant contact (BIC) of one-piece Zr, compared with one-piece Ti implants, placed in the jaws and femurs of domestic sheep. Ten New Zealand mixed breed sheep were used. A One-piece prototype Ti (control) and one Zr (test) implant were placed in the mandible, and one of each implant (Ti and Zr) was placed into the femoral epicondyle of each animal. The femur implants were submerged and unloaded; the mandibular implants were placed using a one-stage transgingival protocol and were nonsubmerged. After a healing period of 12 weeks, %BIC was measured. The overall survival rate for mandibular and femur implants combined was 87.5%. %BIC was higher for Zr implants versus Ti implants in the femur (85.5%, versus 78.9%) ( = 0.002). Zirconia implants in the mandible showed comparable %BIC to titanium implants (72.2%, versus 60.3%) ( = 0.087). High failure rate of both Zr and Ti one-piece implants in the jaw could be attributed to the one-piece design and surface characteristics of the implant that could have influenced osseointegration. Further clinical trials are recommended to evaluate the performance of zirconia implants under loading conditions.
报告记录了牙种植治疗后钛（Ti）过敏的情况。有人提出了替代材料，包括氧化锆（Zr）陶瓷，在动物研究中其骨结合表现可预测，且似乎没有免疫反应。该研究的目的是调查一体式Zr种植体与一体式Ti种植体相比，植入家养绵羊颌骨和股骨后的骨-种植体接触（BIC）情况。使用了10只新西兰杂交绵羊。将一个一体式原型Ti（对照）种植体和一个Zr（测试）种植体植入下颌骨，每种种植体各一个（Ti和Zr）植入每只动物的股骨髁上。股骨种植体被浸没且无负载；下颌种植体采用一期经龈入路植入，未被浸没。在12周的愈合期后，测量BIC百分比。下颌和股骨种植体的总体存活率为87.5%。在股骨中，Zr种植体的BIC百分比高于Ti种植体（85.5%对78.9%）（P = 0.002）。下颌骨中的氧化锆种植体显示出与钛种植体相当的BIC百分比（72.2%对60.3%）（P = 0.087）。Zr和Ti一体式种植体在下颌骨中的高失败率可能归因于种植体的一体式设计和表面特性，这可能影响了骨结合。建议进一步进行临床试验，以评估氧化锆种植体在负载条件下的性能。
