Ophthalmology Department, China-Japan Friendship Hospital, Beijing, China.
Adv Ther. 2021 Apr;38(4):1931-1945. doi: 10.1007/s12325-021-01682-1. Epub 2021 Mar 10.
To evaluate the anatomical and functional outcomes of the inverted internal limiting membrane (ILM) flap technique (IFT) in macular holes (MHs), especially in MHs with a macular hole index (MHI) < 0.5.
This was a retrospective comparative study. Patients with idiopathic MHs who underwent either the IFT or conventional ILM peeling (CP) were investigated. The main outcomes included the MH closure rate, best corrected visual acuity (BCVA), and recovery rates of the external limiting membrane (ELM) and ellipsoid zone (EZ) at 1, 3, and 6 months postoperatively.
Forty-eight eyes of 48 patients who underwent the IFT (n = 29, Group A) or CP (n = 19, Group B) were included. The mean minimal diameter was 522.00 ± 208.08 µm. The closure rate was 100.0% in Group A and 94.7% in Group B (P = 0.396). The mean BCVA and EZ and ELM recovery rates improved significantly in both groups postoperatively. No significant differences in BCVA or the EZ or ELM recovery rates were found between the two groups. Of the 39 eyes whose MHI was < 0.5, 25 underwent the IFT, and 14 underwent CP. Comparing the results of the closure rate, BCVA and recovery rates of the EZ and ELM between groups were similar to those in 48 eyes.
Both the IFT and CP can achieve a high closure rate, with no significant difference in ordinary idiopathic MHs. The IFT does not seem to achieve better anatomical and functional outcomes than CP. The IFT should be used conservatively in ordinary non-refractory MH surgery.
评估内界膜(ILM)翻转瓣技术(IFT)在黄斑裂孔(MH)中的解剖和功能结果,特别是在 MH 指数(MHI)<0.5 的情况下。
这是一项回顾性比较研究。研究对象为接受IFT 或常规 ILM 剥离术(CP)的特发性 MH 患者。主要结果包括 MH 闭合率、最佳矫正视力(BCVA)以及术后 1、3 和 6 个月时外节(ELM)和椭圆体带(EZ)的恢复率。
纳入了 48 例接受 IFT(n=29,A 组)或 CP(n=19,B 组)的患者的 48 只眼。平均最小直径为 522.00±208.08μm。A 组的闭合率为 100.0%,B 组为 94.7%(P=0.396)。两组术后 BCVA 和 EZ 及 ELM 恢复率均显著提高。两组间 BCVA 或 EZ 和 ELM 恢复率无显著差异。在 39 只 MHI<0.5 的眼中,25 只接受 IFT,14 只接受 CP。比较两组间的闭合率、BCVA 和 EZ 及 ELM 恢复率,结果相似。
IFT 和 CP 均可实现较高的闭合率,在普通特发性 MH 中无显著差异。IFT 在解剖和功能结果方面似乎并不优于 CP。在普通非难治性 MH 手术中,IFT 应谨慎使用。