The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
J Am Chem Soc. 2021 Mar 24;143(11):4187-4192. doi: 10.1021/jacs.1c01372. Epub 2021 Mar 9.
The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals and late stage C-H oxidation to incorporate the C7' alcohol.
本文报道了细胞毒生物碱里特灵 B 的首次全合成。该合成采用统一的方法构建甾体两个部分，利用钛介导的炔丙基化反应实现从共同前体的发散。其他关键步骤包括金催化的环异构化，构建螺缩酮和晚期 C-H 氧化以引入 C7' 醇。
