（+）-cephalostatin 1 的对映选择性合成。
Enantioselective synthesis of (+)-cephalostatin 1.
机构信息
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
出版信息
J Am Chem Soc. 2010 Jan 13;132(1):275-80. doi: 10.1021/ja906996c.
PMID:19968285
Abstract
This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C-H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.
摘要
本文描述了cephalostatin 1 的对映选择性合成。该合成的关键步骤包括独特的甲基选择性烯丙基氧化、甾醇 C12 位的导向 C-H 羟化、Au(I)催化的 5-endo-环化以及动力学螺缩酮化。
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