Department of Physiology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Health and Wellness Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Diabetes Metab Syndr. 2021 Mar-Apr;15(2):549-555. doi: 10.1016/j.dsx.2021.02.032. Epub 2021 Mar 3.
Systemic review (SR) and meta-analysis (MA) of interventional studies are considered as the highest level of evidence for clinical decision making. Therefore, we systematically summarized all high-quality evidence on the usage of coconut oil for health-related benefits from SRs and MA.
PubMed®, Web of science®, SciVerse Scopus®, and EMBASE® databases were systematically searched to select SRs and SRs with MA of interventional studies reporting health-related clinical outcomes of coconut oil. Similar studies were grouped based on their respective clinical areas. A methodological quality appraisal was conducted for all included SRs and SRs with MA using the Critical Appraisal Checklist for Systematic Reviews.
A total of seven papers were selected for inclusion in this review, consisting of three MA and one SR on cardio-metabolic health, one SR on oral health, and one SR and one MA each on skin health. Coconut oil significantly increases serum total cholesterol, low-density- and high-density- lipoprotein cholesterol levels compared to poly- and mono-unsaturated oils. Limited studies showed that topical use of coconut oil helps in the prevention and treatment of atopic dermatitis and oil pulling for the prevention of dental caries. All four studies on cardiometabolic health and the SR on oral health had a high score in the quality assessment, SR with MA on skin health fulfilled high-quality scoring whereas the SR on the same topic had a low-quality scoring.
In summary, consistent and strong evidence shows that coconut oil has an adverse effect on the lipids parameters associated with cardio-metabolic health, with limited studies to conclude the effects of atopic dermatitis and oil pulling.
系统评价（SR）和荟萃分析（MA）的干预性研究被认为是临床决策的最高证据级别。因此，我们系统地总结了所有关于椰子油在健康相关益处方面的高质量证据，这些证据来自 SR 和 MA。
系统地检索了 PubMed®、Web of science®、SciVerse Scopus®和 EMBASE®数据库，以选择报告椰子油对健康相关临床结局的干预性研究的 SR 和 MA。将具有相似临床领域的相似研究进行分组。使用系统评价的关键评估清单对所有纳入的 SR 和 MA 进行方法学质量评估。
共有 7 篇论文被纳入本综述，其中包括 3 篇关于心脏代谢健康的 MA 和 1 篇 SR，1 篇关于口腔健康的 SR，1 篇关于皮肤健康的 SR 和 1 篇 MA。与多不饱和和单不饱和油相比，椰子油显著增加血清总胆固醇、低密度和高密度脂蛋白胆固醇水平。有限的研究表明，局部使用椰子油有助于预防和治疗特应性皮炎，以及油拔法预防龋齿。所有四项关于心脏代谢健康的研究和关于口腔健康的 SR 都在质量评估中获得了高分，关于皮肤健康的 MA 满足高质量评分，而关于同一主题的 SR 则获得了低质量评分。
总之，一致且强有力的证据表明，椰子油对与心脏代谢健康相关的脂质参数有不利影响，关于特应性皮炎和油拔法的影响的研究有限。
