Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan.
Department of Pediatrics, College of Medicine, Chang Gung University, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Colloids Surf B Biointerfaces. 2021 Jun;202:111674. doi: 10.1016/j.colsurfb.2021.111674. Epub 2021 Mar 4.
Although considerable efforts have been made to vary the alkyl chain length in the quaternary ammonium compounds (QACs) for optimizing the antibacterial activity, only few researchers have systematically investigated the combinatory effects of alkyl chain length and another acryl monomers with the different chemical configuration on the antibacterial activity of the modified substrate. In this study, by surface grafting of various copolymeric brushes, different modified cotton substrates were prepared by surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization reaction for exploring the effects of alkyl chain length of QACs and the fluorine content on antibacterial and anti-microbial adhesion characteristics. The quaternized monomers used were prepared by quaternization of 2-(dimethylamino) ethyl methacrylate (DMAEMA) with 1-bromooctane (DMAEMA + 8), and 1-bromopropane (DMAEMA + 3). The fluoro-containing monomer was 2,2,2-Trifluoroethyl methacrylate (TFEMA). Ethyl methacrylate (EMA) was also used for comparison. Results have shown that the optimal antibacterial and anti-microbial adhesion characteristics were noted on the substrates grafted with DMAEMA + 8 and TFEMA. This can be attributed to the enhanced degree of surface quaternization due to the hydrophobic interactions between the grafted TFEMA and DMAEMA + 8 chains, leading to an increase in antibacterial efficacy of modified cotton substrates.
尽管人们已经做出了相当大的努力来改变季铵化合物（QACs）中的烷基链长度，以优化其抗菌活性，但只有少数研究人员系统地研究了烷基链长度和具有不同化学结构的另一种丙烯单体的组合效应对改性基底抗菌活性的影响。在这项研究中，通过各种共聚刷的表面接枝，通过表面引发可逆加成-断裂链转移（RAFT）聚合反应制备了不同改性棉基底，以探索 QACs 的烷基链长度和氟含量对抗菌和抗微生物附着特性的影响。使用的季铵化单体是通过 2-（二甲氨基）乙基甲基丙烯酸酯（DMAEMA）与 1-溴辛烷（DMAEMA + 8）和 1-溴丙烷（DMAEMA + 3）的季铵化制备的。含氟单体为 2,2,2-三氟乙基甲基丙烯酸酯（TFEMA）。还使用了乙基甲基丙烯酸酯（EMA）进行比较。结果表明，在接枝有 DMAEMA + 8 和 TFEMA 的基底上，表现出最佳的抗菌和抗微生物附着特性。这可以归因于接枝的 TFEMA 和 DMAEMA + 8 链之间的疏水相互作用增强了表面季铵化程度，从而提高了改性棉基底的抗菌效果。
