Roy Debashish, Knapp Jeremy S, Guthrie James T, Perrier Sébastien
Department of Colour and Polymer Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
Biomacromolecules. 2008 Jan;9(1):91-9. doi: 10.1021/bm700849j. Epub 2007 Dec 8.
2-(dimethylamino)ethyl methacrylate (DMAEMA) was polymerized from cellulosic filter paper via reversible addition-fragmentation chain transfer (RAFT) polymerization. The tertiary amino groups of the grafted PDMAEMA chains were subsequently quaternized with alkyl bromides of different chain lengths (C8-C16) to provide a large concentration of quaternary ammonium groups on the cellulose surface. The antibacterial activity of the quaternized and nonquaternized PDMAEMA-grafted cellulosic fibers was tested against Escherichia coli. The antibacterial activity was found to depend on the alkyl chain length and on the degree of quaternization, i.e., the amount of quaternary amino groups present in the cellulose graft copolymers. The PDMAEMA-grafted cellulose fiber with the highest degree of quaternization and quaternized with the shortest alkyl chains was found to exhibit particularly high activity against E. coli.
通过可逆加成-断裂链转移（RAFT）聚合反应，在纤维素滤纸表面聚合得到了聚甲基丙烯酸2-（二甲氨基）乙酯（PDMAEMA）。随后，将接枝的PDMAEMA链上的叔氨基用不同链长（C8 - C16）的烷基溴进行季铵化处理，从而在纤维素表面形成高浓度的季铵基团。测试了季铵化和未季铵化的PDMAEMA接枝纤维素纤维对大肠杆菌的抗菌活性。结果发现，抗菌活性取决于烷基链长度和季铵化程度，即纤维素接枝共聚物中季铵基团的含量。季铵化程度最高且用最短烷基链进行季铵化的PDMAEMA接枝纤维素纤维对大肠杆菌表现出特别高的活性。
