发出混合信号：多瘤病毒进入和运输。
Sending mixed signals: polyomavirus entry and trafficking.
机构信息
Department of Molecular and Biomedical Sciences, The University of Maine, Orono, ME, USA.
Department of Molecular and Biomedical Sciences, The University of Maine, Orono, ME, USA; Graduate School in Biomedical Sciences and Engineering, The University of Maine, Orono, ME, USA.
出版信息
Curr Opin Virol. 2021 Apr;47:95-105. doi: 10.1016/j.coviro.2021.02.004. Epub 2021 Mar 6.
Polyomaviruses are mostly non-pathogenic, yet some can cause human disease especially under conditions of immunosuppression, including JC, BK, and Merkel cell polyomaviruses. Direct interactions between viruses and the host early during infection dictate the outcome of disease, many of which remain enigmatic. However, significant work in recent years has contributed to our understanding of how this virus family establishes an infection, largely due to advances made for animal polyomaviruses murine and SV40. Here we summarize the major findings that have contributed to our understanding of polyomavirus entry, trafficking, disassembly, signaling, and immune evasion during the infectious process and highlight major unknowns in these processes that are open areas of study.
多瘤病毒大多是非致病性的，但有些病毒会在免疫抑制的情况下引起人类疾病，包括 JC、BK 和 Merkel 细胞多瘤病毒。病毒与宿主在感染早期的直接相互作用决定了疾病的结果，其中许多仍然是神秘的。然而，近年来的大量工作有助于我们了解这个病毒家族是如何建立感染的，这在很大程度上要归功于对动物多瘤病毒（鼠和 SV40）的研究进展。在这里，我们总结了对多瘤病毒进入、运输、解体、信号转导和感染过程中的免疫逃逸的主要发现，并强调了这些过程中主要的未知领域，这些领域是有待研究的。
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