Vasil'ev V N, Chugunov V S, Derbeneva L M, Eremeev M S
Vopr Med Khim. 1988 Jan-Feb;34(1):115-20.
Three groups of patients with morbid fear neurosis, dissimilar in prevailing of either adrenaline or noradrenaline excretion, were identified using the complex method of sympathoadrenal system (SAS) examination. The test with 0.1 g L-DOPA loading demonstrated the high rate of synthesis and high reactivity of SAS in the first two groups with the adrenal type of SAS functioning as well as an increased hydroxylation in the course of synthesis of catecholamines. These anomalies were accompanied by impairments of adrenaline metabolism in the second group. A decreased reactivity of SAS in morning crises and elevated reactivity--during day and evening crises were observed in the third group of patients, characterized by the noradrenaline type of the system functioning as well as by presence of noradrenaline crises.
采用交感肾上腺系统(SAS)综合检查方法,识别出三组患有病态恐惧神经症的患者,他们在肾上腺素或去甲肾上腺素排泄优势方面存在差异。0.1 g左旋多巴负荷试验表明,前两组具有肾上腺型SAS功能,SAS的合成率高且反应性高,儿茶酚胺合成过程中的羟基化增加。这些异常在第二组中伴有肾上腺素代谢障碍。在第三组患者中观察到,SAS在早晨发作时反应性降低,而在白天和晚上发作时反应性升高,其特征为系统功能为去甲肾上腺素型且存在去甲肾上腺素发作。