Karam Bruno, Wilson William D, Chambers Thomas M, Reedy Stephanie, Pusterla Nicola
William R. Pritchard Veterinary Medical Teaching Hospital (Karam), Department of Medicine and Epidemiology (Wilson, Pusterla), School of Veterinary Medicine, University of California, Davis, California, USA; Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky, USA (Chambers, Reedy).
Can Vet J. 2021 Mar;62(3):266-272.
The use of a hemagglutination inhibition (HI) assay to assess humoral immune response to equine influenza virus (EIV) vaccines from various manufacturers administered to previously immunized adult horses was investigated. Subjects were allocated into one of 3 groups and vaccinated with various commercially available vaccines. Groups were subdivided into subjects that received 1 dose of a particular vaccine and those that received a second dose, 30 d later. Serum was collected at various times to assess antibody responses to contemporary EIV Florida sub-lineage strains. Statistical significance was set at < 0.05 and all groups had a significant increase in antibody titers pre- and post-administration of the first dose. In contrast, there was no significant difference between day 30 titers and titers at subsequent time points, regardless of protocol. We concluded that administration of various commercial influenza vaccines containing a different sub-lineage clade stimulated equivalent HI antibody titers after 1 booster vaccination.
研究了使用血凝抑制（HI）试验来评估给先前免疫过的成年马接种不同制造商的马流感病毒（EIV）疫苗后的体液免疫反应。将受试者分为3组之一，并用各种市售疫苗进行接种。每组再细分为接受1剂特定疫苗的受试者和30天后接受第2剂疫苗的受试者。在不同时间收集血清，以评估对当代EIV佛罗里达亚系毒株的抗体反应。统计学显著性设定为<0.05，所有组在首次接种前后抗体滴度均有显著增加。相比之下，无论方案如何，第30天的滴度与后续时间点的滴度之间均无显著差异。我们得出结论，接种一剂加强疫苗后，接种含有不同亚系分支的各种商业流感疫苗可刺激产生相当的HI抗体滴度。
