Bai Yuyan, He Hefan, Zhang Peisen, Liu Weifeng, Huang Lirong
Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China.
Exp Ther Med. 2021 Apr;21(4):406. doi: 10.3892/etm.2021.9837. Epub 2021 Feb 25.
The present study was designed to determine the effects of dexmedetomidine on immune function, renal function and inflammatory factors in patients undergoing percutaneous nephrolithotomy under general anesthesia. A total of 177 patients with kidney calculi who underwent percutaneous nephrolithotomy in The Second Affiliated Hospital of Fujian Medical University were enrolled, in which 91 patients were treated with dexmedetomidine during surgery (research group) and 86 patients were not sedated during surgery (control group). The vital signs, renal function, inflammatory factors and immune function during surgery between the two groups were compared. Patients in the research group showed improved vital signs, renal function, inflammatory factors and immune function compared with the control group (P<0.05), and also experienced a significantly shorter hospitalization time (P<0.001). Therefore, the present results suggested that with a relatively high safety profile, use of dexmedetomidine for sedation can effectively protect renal and immune functions, and reduce the inflammatory response of patients during percutaneous nephrolithotomy. Thus, dexmedetomidine may have be potentially applied in clinical practice.
本研究旨在确定右美托咪定对全身麻醉下行经皮肾镜取石术患者免疫功能、肾功能及炎症因子的影响。选取福建医科大学附属第二医院177例行经皮肾镜取石术的肾结石患者，其中91例患者在手术期间接受右美托咪定治疗（研究组），86例患者在手术期间未进行镇静（对照组）。比较两组患者手术期间的生命体征、肾功能、炎症因子及免疫功能。与对照组相比，研究组患者的生命体征、肾功能、炎症因子及免疫功能均有改善（P<0.05），且住院时间显著缩短（P<0.001）。因此，目前的结果表明，右美托咪定用于镇静具有较高的安全性，可有效保护肾脏和免疫功能，并减轻经皮肾镜取石术患者的炎症反应。因此，右美托咪定可能具有潜在的临床应用价值。
