Takeyasu Rika, Tamura Yuichi, Abe Kohtaro, Goda Ayumi, Satoh Toru, Suda Rika, Tanabe Nobuhiro, Tsujino Ichizo, Yamazaki Tsutomu, Tatsumi Koichiro
Graduate School of Public Health, International University of Health and Welfare Tokyo Japan.
Pulmonary Hypertension Center, International University of Health and Welfare Mita Hospital Tokyo Japan.
Circ Rep. 2020 Mar 20;2(4):255-259. doi: 10.1253/circrep.CR-20-0014.
The emPHasis-10 questionnaire is a disease-specific patient-reported outcome assessment of quality of life (QOL) in pulmonary hypertension (PH). The aim of this study was to psychometrically validate a linguistically validated Japanese version of the emPHasis-10. Japanese patients with PH (age ≥18 years) and no change in functional status, or initiation or change in PH-specific treatment during the past 3 months were recruited from 5 institutions from August 2018 to July 2019. A set of questionnaires was administered twice. The validity and reliability of the emPHasis-10 were assessed using the data of 76 patients. On concurrent validity analysis, a moderate-to-strong correlation was seen with the total score of all 5 external criteria (the Minnesota Living with Heart Failure modified for PH [MLHFQ-PH], Hospital Anxiety and Depression Scale, Dyspnea-12 questionnaire, European Quality of Life-5 Dimensions questionnaire [EQ-5D], and 6-min walk test), with a notably strong correlation with the MLHFQ-PH (0.77) and EQ-5D (-0.64). On known-group validity, a linear increasing trend of the emPHasis-10 score was observed across 4 World Health Organization functional status groups (Jonckheere-Terpstra test, 1-sided, P<0.001). Intraclass correlation coefficient for test-retest reliability was 0.86, and the Cronbach's α for internal consistency was 0.89. The Japanese emPHasis-10 questionnaire is psychometrically valid to evaluate QOL in Japanese PH patients in a clinical setting.
EmPHasis-10问卷是一种针对肺动脉高压（PH）患者生活质量（QOL）的特定疾病患者报告结局评估工具。本研究的目的是对经过语言验证的日语版EmPHasis-10进行心理测量学验证。2018年8月至2019年7月，从5家机构招募了年龄≥18岁、功能状态无变化、过去3个月内未开始或改变PH特异性治疗的日本PH患者。一组问卷进行了两次发放。使用76例患者的数据评估EmPHasis-10的有效性和可靠性。在同时效度分析中，与所有5项外部标准（针对PH修改的明尼苏达心力衰竭生活问卷[MLHFQ-PH]、医院焦虑和抑郁量表、呼吸困难-12问卷、欧洲生活质量-5维度问卷[EQ-5D]和6分钟步行试验）的总分呈中度至强相关，与MLHFQ-PH（0.77）和EQ-5D（-0.64）的相关性尤为显著。在已知组效度方面，观察到EmPHasis-10评分在4个世界卫生组织功能状态组中呈线性增加趋势（Jonckheere-Terpstra检验，单侧，P<0.001）。重测信度的组内相关系数为0.86，内部一致性的Cronbach's α为0.89。日语版EmPHasis-10问卷在临床环境中对评估日本PH患者的生活质量具有心理测量学有效性。
