Rosalind and Morris Goodman Cancer Research Centre, Montreal, Quebec, Canada.
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Biol Reprod. 2021 Jun 4;104(6):1249-1261. doi: 10.1093/biolre/ioab043.
The oviduct/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction, which likely play roles in reproduction. Furthermore, we demarcated the ampulla-isthmus junction as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction.
输卵管是一种管状结构，从子宫延伸到卵巢。它是一个重要的生殖器官，为内部受精和着床前的胚胎发育提供了环境。然而，我们对其区域和细胞异质性的认识仍然有限。在这里，我们使用现代成像技术和荧光报告系来研究小鼠输卵管的解剖复杂性。我们发现，卷曲的小鼠输卵管存在一致的卷曲模式和转折点，这些转折点可以作为管腔形态区域的可靠标志。我们还在峡部和子宫输卵管连接处发现了以前未被识别的解剖结构，这些结构可能在生殖中发挥作用。此外，我们将壶腹-峡部交界处划分为一个独特的区域。综上所述，输卵管黏膜上皮具有高度多样化的结构，具有不同的上皮细胞群体，反映了其在生殖中的复杂功能。
