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Bad company: monocytes in HIV and atherosclerosis.

作者信息

Rohde David, Nahrendorf Matthias

机构信息

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.

Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA02114, USA.

出版信息

Cardiovasc Res. 2021 Mar 21;117(4):993-994. doi: 10.1093/cvr/cvab058.

DOI:10.1093/cvr/cvab058
PMID:33693568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7982997/
Abstract
摘要

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2
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Monocytes from men living with HIV exhibit heightened atherogenic potential despite long-term viral suppression with antiretroviral therapy.尽管接受抗逆转录病毒疗法进行了长期病毒抑制，但 HIV 感染者的单核细胞仍表现出增强的动脉粥样硬化形成潜能。
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Rosuvastatin treatment reduces markers of monocyte activation in HIV-infected subjects on antiretroviral therapy.瑞舒伐他汀治疗可降低接受抗逆转录病毒治疗的HIV感染受试者的单核细胞活化标志物水平。
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本文引用的文献

1
Effects of Influenza Vaccine on Mortality and Cardiovascular Outcomes in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis.流感疫苗对心血管疾病患者死亡率和心血管结局的影响：系统评价和荟萃分析。
J Am Heart Assoc. 2021 Mar 16;10(6):e019636. doi: 10.1161/JAHA.120.019636. Epub 2021 Mar 13.
2
Classical monocyte transcriptomes reveal significant anti-inflammatory statin effect in women with chronic HIV.经典单核细胞转录组揭示了慢性 HIV 女性中具有显著抗炎作用的他汀类药物。
Cardiovasc Res. 2021 Mar 21;117(4):1166-1177. doi: 10.1093/cvr/cvaa188.
3
Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity.可调节心血管风险、造血和先天免疫。
Circ Res. 2020 Apr 24;126(9):1242-1259. doi: 10.1161/CIRCRESAHA.120.315936. Epub 2020 Apr 23.
4
Monocytes from men living with HIV exhibit heightened atherogenic potential despite long-term viral suppression with antiretroviral therapy.尽管接受抗逆转录病毒疗法进行了长期病毒抑制，但 HIV 感染者的单核细胞仍表现出增强的动脉粥样硬化形成潜能。
AIDS. 2020 Mar 15;34(4):513-518. doi: 10.1097/QAD.0000000000002460.
5
The HIV Reservoir in Monocytes and Macrophages.HIV 储库：单核细胞和巨噬细胞。
Front Immunol. 2019 Jun 26;10:1435. doi: 10.3389/fimmu.2019.01435. eCollection 2019.
6
Rationale and design of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE).随机预防 HIV 血管事件试验（REPRIEVE）的原理和设计。
Am Heart J. 2019 Jun;212:23-35. doi: 10.1016/j.ahj.2018.12.016. Epub 2019 Mar 4.
7
Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV: Systematic Review and Meta-Analysis.全球艾滋病毒感染者的动脉粥样硬化性心血管疾病负担：系统评价和荟萃分析。
Circulation. 2018 Sep 11;138(11):1100-1112. doi: 10.1161/CIRCULATIONAHA.117.033369.
8
Risk of Cardiovascular Disease Due to Chronic Hepatitis C Infection: A Review.慢性丙型肝炎感染导致心血管疾病的风险：综述
J Clin Transl Hepatol. 2017 Dec 28;5(4):343-362. doi: 10.14218/JCTH.2017.00021. Epub 2017 Aug 31.
9
Pleiotropic Effects of Statins on the Cardiovascular System.他汀类药物对心血管系统的多效性作用
Circ Res. 2017 Jan 6;120(1):229-243. doi: 10.1161/CIRCRESAHA.116.308537.
10
Mechanisms of Myeloid Cell Modulation of Atherosclerosis.骨髓细胞调节动脉粥样硬化的机制。
Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.MCHD-0026-2015.