School of Chemistry and Chemical Engineering, Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan, 250100, P. R. China.
MOE Key Laboratory of Cluster Science, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, P. R. China.
Angew Chem Int Ed Engl. 2021 May 25;60(22):12490-12497. doi: 10.1002/anie.202100849. Epub 2021 Apr 23.
Imparting mesopores to organic cages of an intrinsic microporous nature to build up hierarchically porous cage soft materials is a grand challenge and will reshape the property and application scope of traditional organic cage molecules. Herein, we discovered how to engineer mesopores into microporous organic cages via their host-guest interactions with long chain ionic surfactants. Equally important, the ionic head of surfactants equips the supramolecularly assembled porous structures with charge-selective uptake and release function in solution. Interestingly, such hierarchically porous organic cage can serve as a nanoreactor once trapping enzymes within the cavity, which show 5-fold enhanced activity of enzymatic catalysis when compared with the free enzymes.
将介孔赋予具有本征微孔性质的有机笼，以构建分级多孔笼状软材料，这是一项重大挑战，将重塑传统有机笼分子的性质和应用范围。在此，我们发现了如何通过与长链离子型表面活性剂的主客体相互作用，将介孔引入微孔有机笼中。同样重要的是，表面活性剂的离子头赋予超分子组装的多孔结构在溶液中具有电荷选择性的吸收和释放功能。有趣的是，这种分级多孔有机笼在捕获空腔内的酶后可以作为纳米反应器，与游离酶相比，酶催化的活性提高了 5 倍。
