Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA.
Adv Healthc Mater. 2021 May;10(9):e2002269. doi: 10.1002/adhm.202002269. Epub 2021 Mar 10.
Tendon-to-bone repair often fails because the functionally graded attachment is not regenerated during the healing process. Biomimetic scaffolds that recapitulate the unique features of the native tendon-to-bone attachment hold great promise for enhancing the healing process. Among various types of scaffolds that are developed and evaluated for tendon-to-bone repair, those with gradations (in either a stratified or a continuous fashion) in composition, structure, mechanical properties, and cell phenotype have gained the most attention. In this progress report, the recent efforts in the rational design and fabrication of functionally graded scaffolds based upon electrospun nanofiber mats and inverse opal structures, as well as the evaluation of their applications in augmenting tendon-to-bone repair, are reviewed. This report concludes with perspectives on the necessary future steps for clinical translation of the scaffolds.
腱骨修复常常失败，因为在愈合过程中功能梯度附着体无法再生。仿生支架能够再现天然腱骨附着体的独特特征，有望增强愈合过程。在为腱骨修复而开发和评估的各种类型的支架中，那些在组成、结构、机械性能和细胞表型方面具有梯度（分层或连续方式）的支架受到了最多的关注。在本进展报告中，我们回顾了基于静电纺纳米纤维垫和反蛋白石结构的功能梯度支架的合理设计和制造方面的最新进展，以及评估它们在增强腱骨修复中的应用的进展。本报告最后对支架进行临床转化所需的未来步骤提出了展望。
