Schreier E, Roeske H, Driesel G, Künkel U, Petzold D R, Berlinghoff R, Michel S
Department of Molecular Biology, Central Institute of Hygiene, Microbiology, and Epidemiology, Berlin, German Democratic Republic.
Arch Virol. 1988;99(3-4):271-6. doi: 10.1007/BF01311076.
The complete nucleotide sequence of the neuraminidase (NA) gene of influenza virus A/Chile/1/83 (H1N1) has been determined after reverse transcription and cloning into the plasmid pAT 153/PvuII/8. The gene is 1461 nucleotides long and codes for a protein of 470 amino acids. The overall nucleotide and predicted amino acid sequence of the A/Chile/1/83 NA exhibits a high homology with other N1 neuraminidases. Hyper-variable regions concerning A to G exchanges are discussed.
通过逆转录并克隆到质粒pAT 153/PvuII/8中，已确定甲型流感病毒A/智利/1/83（H1N1）神经氨酸酶（NA）基因的完整核苷酸序列。该基因长1461个核苷酸，编码一个由470个氨基酸组成的蛋白质。A/智利/1/83 NA的总体核苷酸和预测氨基酸序列与其他N1神经氨酸酶具有高度同源性。讨论了关于A到G交换的高变区。
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