Litvan I, Grafman J, Vendrell P, Martinez J M, Junqué C, Vendrell J M, Barraquer-Bordas J L
Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Arch Neurol. 1988 Jun;45(6):607-10. doi: 10.1001/archneur.1988.00520300025012.
Some patients with multiple sclerosis (MS) demonstrate impaired memory. A group of 16 patients with MS who were mildly to moderately affected (Kurtzke Expanded Disability Status Scale Score = 3.8) were studied, and they were compared with a matched control group on tests of "working memory." The working memory system was explored by evaluating the amount of information that can temporarily be held in a buffer system during encoding. Results indicated that patients with MS have difficulty in processing information at the level of a hypothesized articulatory loop in working memory. This deficit was correlated with their retrieval of verbal information from long-term memory, as well as how accurately they processed verbal information presented at a rapid rate. There was no significant relationship between ratings of MS severity or number of plaques visualized on magnetic resonance imaging scans and the degree of working memory deficit.
一些多发性硬化症（MS）患者存在记忆障碍。研究了一组16名轻度至中度受影响的MS患者（库尔特克扩展残疾状态量表评分=3.8），并将他们与匹配的对照组进行了“工作记忆”测试比较。通过评估在编码过程中可以暂时保存在缓冲系统中的信息量来探索工作记忆系统。结果表明，MS患者在工作记忆中假设的发音回路水平上处理信息存在困难。这种缺陷与他们从长期记忆中检索言语信息的能力以及他们处理快速呈现的言语信息的准确性相关。MS严重程度评分或磁共振成像扫描中可见的斑块数量与工作记忆缺陷程度之间没有显著关系。
