Litvan I, Grafman J, Vendrell P, Martinez J M
Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Arch Neurol. 1988 Mar;45(3):281-5. doi: 10.1001/archneur.1988.00520270059021.
Sixteen patients with a definitive diagnosis of multiple sclerosis (MS) and an equal number of matched controls were administered tests of memory and information processing speed. Results indicated a significant long-term verbal memory impairment in patients with MS, with spared short-term memory and memory scanning. Speed of information processing was evaluated with the Paced Auditory Serial Addition Test. The results for the two highest rates of presentation revealed significantly impaired processing in the MS group. Performance at the higher rates and retrieval of information from long-term memory were significantly correlated. These results suggest that slowed information processing is a deficit that contributes to long-term memory impairment in patients with MS.
对16名确诊为多发性硬化症（MS）的患者以及数量相同的匹配对照组进行了记忆和信息处理速度测试。结果表明，MS患者存在显著的长期言语记忆障碍，短期记忆和记忆扫描功能未受影响。通过听觉序列加法测试评估信息处理速度。在两种最高呈现速率下的测试结果显示，MS组的信息处理能力显著受损。较高速率下的表现与从长期记忆中检索信息的能力显著相关。这些结果表明，信息处理速度减慢是导致MS患者长期记忆障碍的一个缺陷。
