Armstrong C, Onishi K, Robinson K, D'Esposito M, Thompson H, Rostami A, Grossman M
Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104-4283, USA.
Neuropsychologia. 1996 Sep;34(9):853-62. doi: 10.1016/0028-3932(95)00171-9.
Neurocognitive studies of multiple sclerosis (MS) have identified a robust long-term memory deficit. We hypothesized that this is due in part to the limited representation and use of serial order information. MS patients and controls were studied with a supraspan list learning procedure with post-encoding retrieval and recognition trials. MS patients demonstrated post-encoding negative recency with normal recognition, and word order recall was impaired. These findings appear to be in part to difficulty using temporal order cues in long-term memory. Two dissociable memory deficits were identified, suggesting that there are at least two neurocognitive mechanisms underlying memory impairment in MS.
对多发性硬化症（MS）的神经认知研究已经确定存在明显的长期记忆缺陷。我们推测，这部分是由于序列顺序信息的表征和使用受限所致。采用一种超跨度列表学习程序对MS患者和对照组进行了研究，该程序包括编码后检索和识别试验。MS患者在编码后表现出负近因效应，识别正常，且单词顺序回忆受损。这些发现似乎部分是由于在长期记忆中难以使用时间顺序线索。确定了两种可分离的记忆缺陷，这表明MS记忆损害背后至少有两种神经认知机制。
