Wagner H, Kreher B, Jurcic K
Institute of Pharmaceutical Biology, University of Munich, Fed. Rep. of Germany.
Arzneimittelforschung. 1988 Feb;38(2):273-5.
The influence of a broad concentration range of naturally occurring naphthoquinones and other cytotoxic or cytostatic agents (azathioprine, colchicine, cyclophosphamide, fluorouracil, methotrexate and vincristine) on human granulocytes and lymphocytes was investigated in a systematic in vitro study. At high concentrations (100 micrograms-10 ng/ml) nearly all substances showed the known cytotoxic or immunosuppressive effects, whereas most of the same compounds displayed immunostimulating activities at very low concentrations (10 ng-10 fg/ml). After a cold shock or heat treatment lymphocytes became more sensitive against these compounds in the active concentration range than untreated cells. These results possibly give an explanation for the antitumour activity of some plant extracts, for which a direct cytotoxicity due to the applied low dose can be excluded.
在一项系统性的体外研究中，研究了一系列浓度范围的天然萘醌以及其他细胞毒性或细胞抑制性药物（硫唑嘌呤、秋水仙碱、环磷酰胺、氟尿嘧啶、甲氨蝶呤和长春新碱）对人粒细胞和淋巴细胞的影响。在高浓度（100微克 - 10纳克/毫升）时，几乎所有物质都表现出已知的细胞毒性或免疫抑制作用，而大多数相同化合物在极低浓度（10纳克 - 10飞克/毫升）时则表现出免疫刺激活性。经过冷休克或热处理后，淋巴细胞在活性浓度范围内比未处理的细胞对这些化合物更敏感。这些结果可能为某些植物提取物的抗肿瘤活性提供了解释，因为可以排除由于低剂量应用而导致的直接细胞毒性。
