Migonney V, Fougnot C, Jozefowicz M
Laboratoire de Recherches sur les Macromolécules, Université Paris-Nord, Villetaneuse, France.
Biomaterials. 1988 Mar;9(2):145-9. doi: 10.1016/0142-9612(88)90113-5.
In order to prepare tubular materials which could be used in blood-circulating medical devices, polystyrene was grafted by irradiation on to polyethylene tubings. A chemical surface treatment was used which resulted in the functionalization of the inner face of the tubing. This procedure is described and the chemical assessment of the constitution of the functionalized polymer has been completed. Tubing, the inner face of which is made of polyethylene-polystyrene copolymer in which polystyrene moieties were substituted with sulphonate and aspartic acid sulphamid groups, was tested for antithrombic properties in a circulating device under controlled transport conditions and by use of purified proteins.
为了制备可用于血液循环医疗设备的管状材料，通过辐照将聚苯乙烯接枝到聚乙烯管材上。采用了一种化学表面处理方法，使管材内表面功能化。本文描述了该过程，并完成了对功能化聚合物组成的化学评估。对管材进行了测试，其管材内表面由聚乙烯 - 聚苯乙烯共聚物制成，其中聚苯乙烯部分被磺酸盐和天冬氨酸磺酰胺基团取代，在可控运输条件下的循环装置中并使用纯化蛋白对其抗血栓性能进行了测试。
