Migonney V, Fougnot C, Jozefowicz M
Laboratoire de Recherches sur les Macromolécules, CSP, Université Paris-Nord, Villetaneuse, France.
Biomaterials. 1988 Sep;9(5):413-8. doi: 10.1016/0142-9612(88)90005-1.
In previous papers, we described treated tubular materials which exhibit an heparin-like antithrombic activity under dynamic conditions. In order to ascertain the heparin-like mechanism of this activity, we have studied the interactions of thrombin, antithrombin III and thrombin-antithrombin III complex with the inner face of these treated tubings under controlled-flow conditions. Moreover, the kinetics of the adsorption of thrombin were studied at different flow rates to establish the rate-determining step.
在之前的论文中，我们描述了经过处理的管状材料，其在动态条件下表现出类肝素抗血栓活性。为了确定这种活性的类肝素机制，我们研究了凝血酶、抗凝血酶III以及凝血酶 - 抗凝血酶III复合物在可控流动条件下与这些经处理管材内表面的相互作用。此外，还研究了不同流速下凝血酶的吸附动力学，以确定速率决定步骤。
