辣椒素应用于人体鼻黏膜所引起的分泌、疼痛及喷嚏反应。
Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man.
作者信息
Geppetti P, Fusco B M, Marabini S, Maggi C A, Fanciullacci M, Sicuteri F
机构信息
Institute of Internal Medicine and Clinical Pharmacology, University of Florence, Italy.
出版信息
Br J Pharmacol. 1988 Mar;93(3):509-14. doi: 10.1111/j.1476-5381.1988.tb10305.x.
Abstract
- Topical application of capsaicin to the human nasal mucosa induced a burning sensation and sneezing. A dose-dependent seromucous nasal secretion was also observed. Capsaicin (75 micrograms) was more potent than methacholine (50 mg) in producing nasal secretion, while topical histamine (200 micrograms), substance P (135 micrograms) and calcitonin gene-related peptide (36 micrograms) did not induce rhinorrhea. 2. Pretreatment with either topical ipratropium bromide, systemic dexchlorpheniramine or indomethacin did not influence the effects induced by capsaicin. Topical pretreatment with lidocaine inhibited the painful sensation but failed to block the rhinorrhea. Desensitization to the effects of capsaicin occurred following 4-5 subsequent applications, and full recovery was observed within 30-40 days. 3. It is proposed that the effects of capsaicin in human nasal mucosa are due to excitation of primary afferent neurones that (a) convey burning and painful sensation, (b) evoke a sneezing reflex and (c) induce nasal secretion by releasing transmitter(s) from their peripheral terminals.
摘要
- 将辣椒素局部应用于人体鼻黏膜会引起灼烧感和打喷嚏。还观察到剂量依赖性的浆液性鼻分泌物。在产生鼻分泌物方面，辣椒素（75微克）比乙酰甲胆碱（50毫克）更有效，而局部应用组胺（200微克）、P物质（135微克）和降钙素基因相关肽（36微克）不会引起鼻漏。2. 局部应用异丙托溴铵、全身应用右氯苯那敏或吲哚美辛预处理均不影响辣椒素所诱导的效应。利多卡因局部预处理可抑制疼痛感觉，但未能阻断鼻漏。在随后4 - 5次应用后，对辣椒素的效应出现脱敏，30 - 40天内观察到完全恢复。3. 有人提出，辣椒素在人体鼻黏膜中的效应是由于初级传入神经元的兴奋，这些神经元：(a) 传递灼烧和疼痛感觉，(b) 引发打喷嚏反射，以及 (c) 通过从其外周终末释放递质来诱导鼻分泌物。
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Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man.辣椒素应用于人体鼻黏膜所引起的分泌、疼痛及喷嚏反应。
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