辣椒素吸入对人体的影响及色甘酸钠的作用。
Capsaicin inhalation in man and the effects of sodium cromoglycate.
作者信息
Collier J G, Fuller R W
出版信息
Br J Pharmacol. 1984 Jan;81(1):113-7. doi: 10.1111/j.1476-5381.1984.tb10750.x.
Abstract
The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2-65 mumol 1(-1), caused dose-dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on forced expiratory volume in 1 s (FEV1) measured at the 1st, 5th and 9th min after the challenge was completed. Coughing started within seconds of applying the face mask, continued throughout the minute of capsaicin inhalation, and stopped within seconds of the mask being removed. In any one subject the number of coughs was reproducible when repeated on the same day or after an interval of several days. Experiments using local anaesthesia applied to the buccal mucosa or larynx indicated that the cough was caused by the stimulation of capsaicin-sensitive nerve terminals situated in the larynx. Cough response was not altered by the prior inhalation of sodium cromoglycate.
摘要
通过雾化浓度为2 - 65μmol 1(-1)的辣椒素溶液以气雾剂形式给药，让正常志愿者和轻度哮喘患者吸入辣椒素1分钟，会引起剂量依赖性咳嗽。辣椒素不会引起呼吸困难的感觉，并且在激发试验完成后的第1、5和9分钟测量的1秒用力呼气量（FEV1）上没有影响。咳嗽在戴上面罩后的几秒钟内开始，在吸入辣椒素的整个分钟内持续，并在摘下面罩后的几秒钟内停止。在任何一名受试者中，当在同一天重复或间隔几天后重复时，咳嗽次数是可重复的。对颊黏膜或喉部应用局部麻醉的实验表明，咳嗽是由位于喉部的辣椒素敏感神经末梢受到刺激引起的。预先吸入色甘酸钠不会改变咳嗽反应。
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