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Ann Lab Med. 2021 Mar 1;41(2):129-138. doi: 10.3343/alm.2021.41.2.129.
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ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population.ACE2 基因变异可能是意大利人群中个体间对 COVID-19 易感性和差异性的基础。
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The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19.血管紧张素转换酶2的两面性：血管紧张素转换酶2受体及其多态性在高血压和2019冠状病毒病中的作用
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New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis.对 COVID-19 遗传易感性的新认识：ACE2 和 TMPRSS2 多态性分析。
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ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome.ACE2 受体多态性：易感性、高血压、多器官衰竭与 COVID-19 疾病结局。
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Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations.新型冠状病毒（2019-nCoV/SARS-CoV-2）受体ACE2在不同人群中的比较遗传分析。
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Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease?候选基因与全基因组关联分析：哪种方法更适合检测传染病的遗传易感性？
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ACE2 基因多态性在高暴露但未感染的医护人员中对 SARS-CoV-2 易感性的作用。

Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers.

机构信息

Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, Spain.

CIBERER-Genomic Medicine Group, University of Santiago de Compostela, Santiago de Compostela, Spain.

出版信息

Emerg Microbes Infect. 2021 Dec;10(1):493-496. doi: 10.1080/22221751.2021.1902755.

DOI:10.1080/22221751.2021.1902755
PMID:33704002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7993370/
Abstract

We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.

摘要

我们旨在评估血管紧张素转换酶 2 单核苷酸多态性在 SARS-CoV-2 感染易感性中的作用。我们纳入了 28 名未感染但高度暴露的医护人员和 39 名 COVID-19 住院患者。合理选择了 35 个单核苷酸多态性。有两个变异与 SARS-CoV-2 易感性增加相关：rs2106806 变异的次要 A 等位基因（OR 3.75 [95% CI 1.23-11.43]）和 rs6629110 变异的次要 T 等位基因（OR 3.39 [95% CI 1.09-10.56]）。评估遗传变异在 SARS-CoV-2 感染易感性中的作用，有助于识别更易受感染的个体，并为 COVID-19 患者提供潜在的药物靶点。