ACE2 基因多态性在高暴露但未感染的医护人员中对 SARS-CoV-2 易感性的作用。
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers.
机构信息
Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, Facultad de Medicina, Universidad de Alcalá, IRYCIS, Madrid, Spain.
CIBERER-Genomic Medicine Group, University of Santiago de Compostela, Santiago de Compostela, Spain.
出版信息
Emerg Microbes Infect. 2021 Dec;10(1):493-496. doi: 10.1080/22221751.2021.1902755.
Abstract
We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.
摘要
我们旨在评估血管紧张素转换酶 2 单核苷酸多态性在 SARS-CoV-2 感染易感性中的作用。我们纳入了 28 名未感染但高度暴露的医护人员和 39 名 COVID-19 住院患者。合理选择了 35 个单核苷酸多态性。有两个变异与 SARS-CoV-2 易感性增加相关：rs2106806 变异的次要 A 等位基因（OR 3.75 [95% CI 1.23-11.43]）和 rs6629110 变异的次要 T 等位基因（OR 3.39 [95% CI 1.09-10.56]）。评估遗传变异在 SARS-CoV-2 感染易感性中的作用，有助于识别更易受感染的个体，并为 COVID-19 患者提供潜在的药物靶点。
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