School of Behavioral Sciences, Academic College of Tel Aviv-Jaffa, Tel‑Aviv‑Jaffa, Israel.
Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Exp Aging Res. 2021 Jul-Sep;47(4):347-356. doi: 10.1080/0361073X.2021.1898182. Epub 2021 Mar 11.
To assess whether the Rey Auditory Verbal Learning Test (RAVLT) could differentiate deterioration from Mild Cognitive Impairment (MCI) to dementia.
Twenty-six participants who were diagnosed with MCI performed the RAVLT and the Mini Mental State Examination (MMSE) at baseline and after nearly a decade (M = 8.8 years, SD = 3.16), in order to evaluate whether they progressed to dementia.
Twelve participants [5 males, 7 females; age M = 63.7 (7.7)] kept their diagnoses of MCI; 14 participants [11 males, 3 females; age M = 75.0 (6.5)] converted to dementia. Both groups had similar MMSE scores at baseline [26.6 (0.6); and 26.6 (0.7) respectively]. Significant differences between dementia and MCI groups were found on most measures of the RAVLT at baseline: Immediate memory [ = .04], delayed recall [ = .003], total learning [ = .01], learning rate [ = .002], retrieval efficiency [ = .004], and false alarms [ = .004]. Thus, the RAVLT results were significantly worse at baseline in those who later converted. The results remain the same when controlling for age.
The results extend previous findings with follow-up of nearly a decade demonstrating that most of the RAVLT measures are sensitive to differentiate conversion from MCI to dementia.
评估 Rey 听觉言语学习测验（RAVLT）是否能够区分从轻度认知障碍（MCI）到痴呆的恶化。
26 名被诊断为 MCI 的参与者在基线时和近十年后（M=8.8 年，SD=3.16）进行了 RAVLT 和 Mini 精神状态检查（MMSE），以评估他们是否进展为痴呆。
12 名参与者[5 名男性，7 名女性；年龄 M=63.7（7.7）]保持 MCI 的诊断；14 名参与者[11 名男性，3 名女性；年龄 M=75.0（6.5）]转化为痴呆。两组在基线时的 MMSE 评分相似[分别为 26.6（0.6）和 26.6（0.7）]。在基线时，痴呆组和 MCI 组在 RAVLT 的大多数测量中存在显著差异：即时记忆[=0.04]、延迟回忆[=0.003]、总学习[=0.01]、学习率[=0.002]、检索效率[=0.004]和错误警报[=0.004]。因此，在后来转化为痴呆的患者中，RAVLT 的结果在基线时明显更差。当控制年龄时，结果仍然相同。
这些结果扩展了以前的研究结果，随访时间近十年，表明 RAVLT 的大多数测量指标都能敏感地区分从 MCI 到痴呆的转化。
