Department of Oral and Maxillofacial Surgery, College of Dentistry, Taibah University, Madinah, Saudi Arabia.
Faculty of Biology, Medicine and Health, Division of Dentistry, the University of Manchester, Manchester, United Kingdom.
J Craniofac Surg. 2021;32(2):505-508. doi: 10.1097/SCS.0000000000007071.
The purpose of the present study was to systematically review literature relating to the quality of life (QoL) in adult individuals with cleft lip and/or palate (CLP) and identify which aspect of QoL adults with CLP find to be the most problematic, in comparison to a general non-cleft population.
Different databases were searched for this review including the Cochrane Central Register of Controlled Trials, Ovid MEDLINE and Embase. Five domains of QoL were identified to evaluate the overall results of these QoL measures. These domains were; physical function, physical pain, psychological implications and self-esteem, self-perception in relation to facial aesthetics, and social function. The studies included underwent critical appraisal and different types of bias were assessed based on the Cochrane handbook for systematic reviews of interventions.
Ten studies were included in this review. The total number of participants was 541. The most common QoL measure for adults with CLP was Short-Form (SF-36). Seven studies out of 10 reported statistically significantly worse scores (P < 0.05) in the psychological implications and self-esteem domains of QoL in adults with CLP, indicating lower QoL in terms of these domains. The least affected QoL domain was physical function. A high heterogeneity was found among the studies, including variation in the QoL measures, types of orofacial clefts, types of treatment and comparison groups.
The presence of CLP did seem to negatively affect the QoL for adults with CLP, mainly in terms of psychological implications and self-esteem.
本研究旨在系统回顾与唇腭裂（CLP）成年个体生活质量（QoL）相关的文献，并确定与一般非唇腭裂人群相比，CLP 成年个体认为哪些方面的 QoL 最成问题。
为了进行本次综述，我们在 Cochrane 对照试验中心注册数据库、Ovid MEDLINE 和 Embase 等不同数据库中进行了检索。我们确定了五个 QoL 领域来评估这些 QoL 测量的总体结果。这些领域包括：身体功能、身体疼痛、心理影响和自尊、与面部美学相关的自我感知，以及社会功能。纳入的研究经过了严格评估，并根据 Cochrane 干预系统评价手册评估了不同类型的偏倚。
本综述共纳入了 10 项研究。共有 541 名参与者。CLP 成年个体最常用的 QoL 测量方法是短式健康调查量表（SF-36）。10 项研究中有 7 项报告称，CLP 成年个体在 QoL 的心理影响和自尊领域的评分存在统计学上的显著差异（P<0.05），这表明这些领域的 QoL 较低。受影响最小的 QoL 领域是身体功能。研究之间存在高度异质性，包括 QoL 测量方法、唇腭裂类型、治疗类型和对照组的差异。
CLP 的存在似乎确实会对 CLP 成年个体的 QoL 产生负面影响，主要是在心理影响和自尊方面。
