Universiti Kebangsaan Malaysia, Faculty of Health Science, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.
Med J Malaysia. 2023 Mar;78(2):250-258.
Cleft lip and palate (CL/P) are among the most common congenital abnormalities. The purpose of the present study was to review the literature relating to the quality of life (QoL) in young patients with cleft lip and/or palate (CL/P) and to identify the specific aspect of QoL in young patients with CL/P that is mostly affected. Other associated variables within studies that may have an impact on QoL were also identified.
Systematic searches of PubMed, Scopus and Web of Science databases were conducted. Independent reviewers screened the title, abstract and full texts according to predetermined inclusion and exclusion criteria. Articles published in English from January 2012 to March 2022 reporting the QoL of non-syndromic young patients aged 7-18 years with CL/P were included. Review articles and articles reporting the psychological adjustment of parents or other family members with CL/P were excluded.
975 publications were identified, of which 20 studies met our inclusion criteria. The majority of studies reported that the CL/P condition has a negative impact on the QoL. Psychological health, functional well-being, socialemotional well-being and school environment are domains that are affected. Compared with typically developing young patients, those with CL/P had lower QoL scores even though QoL was assessed using different instruments across studies. The impact of CL/P on overall QoL scores varied by age but not gender or cleft type.
Our reviews had shown the presence of CL/P negatively affects the QoL of young patients. Psychological health is the most affected QoL domain. Understanding the impacted domain will help in planning and delivering better health care for individuals with CL/P and reducing the stigma commonly associated with CL/P. Future studies should target intervention on psychological health and consider resilience factors towards positive adjustment.
唇腭裂（CL/P）是最常见的先天性畸形之一。本研究旨在回顾与唇裂/腭裂（CL/P）年轻患者生活质量（QoL）相关的文献，并确定 CL/P 年轻患者受影响最大的 QoL 特定方面。还确定了研究中可能对 QoL 产生影响的其他相关变量。
对 PubMed、Scopus 和 Web of Science 数据库进行系统检索。独立审查员根据预先确定的纳入和排除标准筛选标题、摘要和全文。纳入了 2012 年 1 月至 2022 年 3 月期间以英语发表的报告非综合征性 7-18 岁 CL/P 年轻患者 QoL 的研究。排除综述文章和报告 CL/P 父母或其他家庭成员心理调整的文章。
确定了 975 篇出版物，其中 20 项研究符合我们的纳入标准。大多数研究报告称，CL/P 状况对 QoL 有负面影响。心理健康、功能健康、社会情感健康和学校环境是受影响的领域。与发育正常的年轻患者相比，即使在不同研究中使用不同的工具评估 QoL，CL/P 患者的 QoL 评分也较低。CL/P 对总体 QoL 评分的影响因年龄而异，但与性别或裂隙类型无关。
我们的综述表明，CL/P 的存在会对年轻患者的生活质量产生负面影响。心理健康是受影响最大的 QoL 领域。了解受影响的领域将有助于为 CL/P 患者规划和提供更好的医疗保健，并减少与 CL/P 相关的常见耻辱感。未来的研究应针对心理健康干预，并考虑积极调整的弹性因素。
