Academic Research Centers, NORC at the University of Chicago, Chicago, IL 60637, USA.
Institute for Demographic Research, Federal Center of Theoretical and Applied Sociology, Russian Academy of Sciences, Moscow, 109028, Russia.
Biochemistry (Mosc). 2020 Dec;85(12):1499-1504. doi: 10.1134/S0006297920120032.
Promising ideas and directions for further research into biology of aging are discussed using analysis of the age-related kinetics of organisms' mortality. It is shown that the traditional evolutionary theory explaining aging by decreasing force of natural selection with age is not consistent with the data on age-related mortality kinetics. The hypothesis of multistage destruction of organisms with age, including the rate-limiting stage of transition to a state of non-specific vulnerability ("non-survivor"), is discussed. It is found that the effect of the COVID-19 coronavirus infection on mortality is not additive (as it was the case with the Spanish flu epidemic in 1918), but multiplicative (proportional) for ages over 65 years.
使用对生物体死亡率的年龄相关动力学的分析，讨论了衰老生物学进一步研究的有希望的思路和方向。研究表明，通过随着年龄的增长降低自然选择力来解释衰老的传统进化理论与关于与年龄相关的死亡率动力学的数据不一致。讨论了包括向非特异性脆弱性状态（“非幸存者”）过渡的限速阶段在内的生物体随年龄多阶段破坏的假说。结果发现，COVID-19 冠状病毒感染对死亡率的影响不是加性的（如 1918 年西班牙流感大流行那样），而是超 65 岁人群的比例性的（成比例的）。
