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人类基因混合。

Human genetic admixture.

机构信息

Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America.

出版信息

PLoS Genet. 2021 Mar 11;17(3):e1009374. doi: 10.1371/journal.pgen.1009374. eCollection 2021 Mar.

Abstract

Throughout human history, large-scale migrations have facilitated the formation of populations with ancestry from multiple previously separated populations. This process leads to subsequent shuffling of genetic ancestry through recombination, producing variation in ancestry between populations, among individuals in a population, and along the genome within an individual. Recent methodological and empirical developments have elucidated the genomic signatures of this admixture process, bringing previously understudied admixed populations to the forefront of population and medical genetics. Under this theme, we present a collection of recent PLOS Genetics publications that exemplify recent progress in human genetic admixture studies, and we discuss potential areas for future work.

摘要

纵观人类历史,大规模的迁徙促进了具有来自多个先前分离的人群的祖先的人群的形成。这一过程通过重组导致遗传祖先的后续混合,从而在人群之间、人群中的个体之间以及个体的基因组内产生遗传祖先的变化。最近的方法和实证发展阐明了这种混合过程的基因组特征,使以前研究不足的混合人群成为人口和医学遗传学的前沿。在这个主题下,我们展示了最近的 PLOS 遗传学出版物的集合,这些出版物体现了人类遗传混合研究的最新进展,并讨论了未来工作的潜在领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb9e/7951803/01673377c55b/pgen.1009374.g001.jpg

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