肠道真菌本土化养殖可抵御危险外来物种入侵。
Local farming of gut fungi protects against dangerous imports.
机构信息
Departments of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Cell Host Microbe. 2021 Mar 10;29(3):311-312. doi: 10.1016/j.chom.2021.02.014.
Abstract
Candida albicans is viewed as a harmless commensal in health and a dangerous parasite in disease. Recently in Cell, Doron et al. (2021) reveal that C. albicans in the gut additionally serves as a mutualist by provoking the immune system to generate far-reaching antibodies that defend against invasive fungal infections.
摘要
白色念珠菌在健康时被视为无害共生体，而在疾病时则是危险的寄生虫。最近，在《细胞》杂志上，多隆等人（2021 年）揭示了肠道中的白色念珠菌通过刺激免疫系统产生广泛的抗体来抵御侵袭性真菌感染，从而起到共生体的作用。
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本文引用的文献
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Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies.人类肠道共生真菌通过 CARD9 依赖性诱导抗真菌 IgG 抗体来调节免疫。
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Gut Mycobiota in Immunity and Inflammatory Disease.肠道共生真菌与免疫和炎症性疾病
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Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.人类抗真菌 Th17 免疫和病理学依赖于对白念珠菌的交叉反应性。
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SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.SYK-CARD9 信号轴促进肠道真菌介导体炎性小体激活，以限制结肠炎和结肠癌。
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CX3CR1 mononuclear phagocytes control immunity to intestinal fungi.CX3CR1单核吞噬细胞控制对肠道真菌的免疫。
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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.CARD9通过改变肠道微生物群将色氨酸代谢为芳烃受体配体的过程来影响结肠炎。
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Human nutrition, the gut microbiome and the immune system.人体营养、肠道微生物组与免疫系统。
Nature. 2011 Jun 15;474(7351):327-36. doi: 10.1038/nature10213.
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Nature. 2011 May 12;473(7346):174-80. doi: 10.1038/nature09944. Epub 2011 Apr 20.
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A homozygous CARD9 mutation in a family with susceptibility to fungal infections.一个对真菌感染易感的家族中的纯合CARD9突变。
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