Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, Pittsburgh, Pennsylvania; Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, Pittsburgh, Pennsylvania.
Cell Mol Gastroenterol Hepatol. 2021;12(3):1061-1072. doi: 10.1016/j.jcmgh.2021.02.014. Epub 2021 Mar 8.
Chronic liver disease is one of the leading causes of death in the United States. Coagulopathy is often a sequela of chronic liver disease, however, the role and regulation of coagulation components in chronic liver injury remain poorly understood. Clinical and experimental evidence indicate that misexpression of the procoagulant factor VIII (FVIII) is associated with chronic liver disease. Nevertheless, the molecular mechanism of FVIII-induced chronic liver injury progression remains unknown. This review provides evidence supporting a pathologic role for FVIII in the development of chronic liver disease using both experimental and clinical models.
慢性肝病是美国主要死亡原因之一。凝血障碍通常是慢性肝病的后遗症，然而，凝血成分在慢性肝损伤中的作用和调节仍知之甚少。临床和实验证据表明，促凝因子 VIII (FVIII) 的异常表达与慢性肝病有关。然而，FVIII 诱导的慢性肝损伤进展的分子机制尚不清楚。本综述提供了使用实验和临床模型支持 FVIII 在慢性肝病发展中具有病理作用的证据。
