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多囊卵巢综合征与其皮肤表现之间的关联。

The Association Between Polycystic Ovary Syndrome and Its Dermatological Manifestations.

作者信息

Sekhon Amanpreet Kaur, Zergham Azka Shahid, Tserenpil Gantuya, Mebasher Amal, Malik Bilal Haider

机构信息

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

出版信息

Cureus. 2020 Feb 3;12(2):e6855. doi: 10.7759/cureus.6855.

DOI:10.7759/cureus.6855
PMID:32181090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7053678/
Abstract

Polycystic ovary syndrome (PCOS) commonly occurs in reproductive-age females. It elevates the hormonal levels, creates an imbalance in the metabolic system, and affects their reproductive system too. A number of studies have been conducted on PCOS, and it has been diagnosed together with several dermatological conditions. In this paper, we attempt a traditional review to study the relationship between PCOS and its cutaneous manifestations the patients are predisposed to. To uncover this association, we gathered information from English-language articles on the Pubmed database using six keywords. Materials were also collected from studies done on animal models, which helped in putting down all the data together and interlinking them with other studies. From this data collection, it is ultimately concluded that the association between PCOS and dermatological conditions is a very intricate interconnecting network comprising many factors, such as inflammation, genetics, and hormonal. This study raises some questions that are still unanswered. We believe further research is needed to uncover the various facts about this disease and its associations, in order to make its management more effective. As there is a strong association between PCOS and certain dermatological disorders, it is recommended to develop a questionnaire that should be distributed to every woman who presents to dermatology departments with symptoms that are linked to PCOS, as it will help in diagnosing the condition at an early stage.

摘要

多囊卵巢综合征(PCOS)常见于育龄女性。它会提高激素水平,造成代谢系统失衡,还会影响生殖系统。针对PCOS已经开展了大量研究,并且它已与多种皮肤病一同被诊断出来。在本文中,我们尝试进行一项传统综述,以研究PCOS与其患者易患的皮肤表现之间的关系。为揭示这种关联,我们使用六个关键词从PubMed数据库中的英文文章收集信息。还从对动物模型进行的研究中收集材料,这有助于汇总所有数据并将它们与其他研究相互联系起来。从这次数据收集最终得出结论,PCOS与皮肤病之间的关联是一个非常复杂的相互联系网络,包含许多因素,如炎症、遗传和激素。本研究提出了一些仍未得到解答的问题。我们认为需要进一步研究以揭示关于这种疾病及其关联的各种事实,以便使其管理更加有效。由于PCOS与某些皮肤病之间存在密切关联,建议制定一份问卷,分发给每一位因与PCOS相关症状前往皮肤科就诊的女性,因为这将有助于早期诊断病情。

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本文引用的文献

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Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity.多囊卵巢综合征:高雄激素血症、胰岛素抵抗与肥胖的相关性。
Clin Chim Acta. 2020 Mar;502:214-221. doi: 10.1016/j.cca.2019.11.003. Epub 2019 Nov 13.
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The CYP17 MSP AI (T-34C) and CYP19A1 (Trp39Arg) variants in polycystic ovary syndrome: A case-control study.多囊卵巢综合征中CYP17 MSP AI(T-34C)和CYP19A1(Trp39Arg)变体:一项病例对照研究。
Int J Reprod Biomed. 2019 May 5;17(3):201-8. doi: 10.18502/ijrm.v17i3.4519. eCollection 2019 Mar.
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LKB1 suppresses androgen synthesis in a mouse model of hyperandrogenism via IGF-1 signaling.在雄激素过多的小鼠模型中,LKB1 通过胰岛素样生长因子-1(IGF-1)信号通路抑制雄激素合成。
FEBS Open Bio. 2019 Oct;9(10):1817-1825. doi: 10.1002/2211-5463.12723. Epub 2019 Sep 12.
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Androgen upregulates NR4A1 via the TFAP2A and ETS signaling networks.雄激素通过 TFAP2A 和 ETS 信号网络上调 NR4A1。
Int J Biochem Cell Biol. 2019 Aug;113:1-7. doi: 10.1016/j.biocel.2019.05.015. Epub 2019 May 27.
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Male PCOS equivalent and nutritional restriction: Are we stepping forward?男性 PCOS 等效与营养限制:我们是否在前进?
Med Hypotheses. 2019 May;126:1-3. doi: 10.1016/j.mehy.2019.03.003. Epub 2019 Mar 5.
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The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome.多囊卵巢综合征不同表型中代谢综合征的患病率。
Rev Bras Ginecol Obstet. 2019 Jan;41(1):37-43. doi: 10.1055/s-0038-1676568. Epub 2019 Feb 4.
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Increased IL-17-expressing γδ T cells in seborrhoeic dermatitis-like lesions of the Mpzl3 knockout mice.Mpzl3 基因敲除小鼠皮脂溢性皮炎样皮损中白细胞介素-17 表达的 γδ T 细胞增加。
Exp Dermatol. 2018 Dec;27(12):1408-1411. doi: 10.1111/exd.13798.
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Characterization of comorbid conditions burdening hidradenitis suppurativa: a multicentric observational study.描述性研究:共病负担对化脓性汗腺炎的影响。
G Ital Dermatol Venereol. 2020 Jun;155(3):335-340. doi: 10.23736/S0392-0488.18.06165-5. Epub 2018 Oct 3.
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Insulin resistance in hidradenitis suppurativa: a case-control study.化脓性汗腺炎中的胰岛素抵抗:一项病例对照研究。
J Eur Acad Dermatol Venereol. 2018 May;32(5):820-824. doi: 10.1111/jdv.14894. Epub 2018 Mar 23.
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Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis.多囊卵巢综合征中脂质代谢基因的异常表达和 DNA 甲基化:对其发病机制的新认识。
Clin Epigenetics. 2018 Jan 12;10:6. doi: 10.1186/s13148-018-0442-y. eCollection 2018.