追踪 SARS-CoV-2 谱系 B.1.1.7 的传播：来自全国范围内刺突基因目标失败（SGTF）和刺突基因晚期检测（SGTL）数据的见解，葡萄牙，2020 年第 49 周至 2021 年第 3 周。
Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021.
机构信息
Bioinformatics Unit, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge (INSA), Lisbon, Portugal.
These authors contributed equally to this work.
出版信息
Euro Surveill. 2021 Mar;26(10). doi: 10.2807/1560-7917.ES.2021.26.10.2100130.
We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.
我们表明，SARS-CoV-2 的 B.1.1.7 谱系在葡萄牙高度传播，到 2021 年第 3 周为止，每周 B.1.1.7 比例增加的几率估计为 89%（95%置信区间：83-95%）。实时聚合酶链反应（RT-PCR）棘突基因目标物晚期检测（SGTL）除了棘突基因目标物失败（SGTF）代理外，还可以构成追踪 B.1.1.7 传播的有用替代物。SGTL/SGTF 样本与统计学上显著更高的病毒载量相关，但与非 SGTF/SGTL 病例相比，年龄分布没有实质性变化。
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