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SARS-CoV-2 B.1.1.7 谱系的出现 - 美国,2020 年 12 月 29 日-2021 年 1 月 12 日。

Emergence of SARS-CoV-2 B.1.1.7 Lineage - United States, December 29, 2020-January 12, 2021.

出版信息

MMWR Morb Mortal Wkly Rep. 2021 Jan 22;70(3):95-99. doi: 10.15585/mmwr.mm7003e2.

Abstract

On December 14, 2020, the United Kingdom reported a SARS-CoV-2 variant of concern (VOC), lineage B.1.1.7, also referred to as VOC 202012/01 or 20I/501Y.V1.* The B.1.1.7 variant is estimated to have emerged in September 2020 and has quickly become the dominant circulating SARS-CoV-2 variant in England (1). B.1.1.7 has been detected in over 30 countries, including the United States. As of January 13, 2021, approximately 76 cases of B.1.1.7 have been detected in 12 U.S. states. Multiple lines of evidence indicate that B.1.1.7 is more efficiently transmitted than are other SARS-CoV-2 variants (1-3). The modeled trajectory of this variant in the U.S. exhibits rapid growth in early 2021, becoming the predominant variant in March. Increased SARS-CoV-2 transmission might threaten strained health care resources, require extended and more rigorous implementation of public health strategies (4), and increase the percentage of population immunity required for pandemic control. Taking measures to reduce transmission now can lessen the potential impact of B.1.1.7 and allow critical time to increase vaccination coverage. Collectively, enhanced genomic surveillance combined with continued compliance with effective public health measures, including vaccination, physical distancing, use of masks, hand hygiene, and isolation and quarantine, will be essential to limiting the spread of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). Strategic testing of persons without symptoms but at higher risk of infection, such as those exposed to SARS-CoV-2 or who have frequent unavoidable contact with the public, provides another opportunity to limit ongoing spread.

摘要

2020 年 12 月 14 日,英国报告了一种令人关注的 SARS-CoV-2 变体(VOC),谱系 B.1.1.7,也称为 VOC 202012/01 或 20I/501Y.V1.*。据估计,B.1.1.7 变体于 2020 年 9 月出现,并迅速成为英格兰主要流行的 SARS-CoV-2 变体(1)。B.1.1.7 已在包括美国在内的 30 多个国家被检测到。截至 2021 年 1 月 13 日,在美国的 12 个州已检测到约 76 例 B.1.1.7。多种证据表明,B.1.1.7 的传播效率高于其他 SARS-CoV-2 变体(1-3)。该变体在美国的模型轨迹显示,其在 2021 年初迅速增长,到 3 月成为主要变体。SARS-CoV-2 传播的增加可能威胁到紧张的医疗资源,需要延长和更严格地实施公共卫生策略(4),并增加控制大流行所需的人口免疫率。现在采取措施减少传播,可以减轻 B.1.1.7 的潜在影响,并为增加疫苗接种覆盖率争取宝贵时间。总之,加强基因组监测并继续遵守有效的公共卫生措施,包括接种疫苗、保持社交距离、使用口罩、保持手部卫生以及隔离和检疫,对于限制 SARS-CoV-2 的传播至关重要,该病毒引起 2019 年冠状病毒病(COVID-19)。对无症状但感染风险较高的人进行战略性检测,例如那些接触过 SARS-CoV-2 或经常与公众接触的人,是限制持续传播的另一个机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e4/7821772/a797162c517b/mm7003e2-F1.jpg

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