Wang Xiaolong, Zhang Dan, Jiang Haiqiang, Zhang Shuo, Pang Xiaogang, Gao Shijie, Zhang Huimin, Zhang Shanyu, Xiao Qiuyue, Chen Liyuan, Wang Shengqi, Qi Dongmei, Li Yunlun
Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China.
Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China.
Front Microbiol. 2021 Feb 23;11:576061. doi: 10.3389/fmicb.2020.576061. eCollection 2020.
Ginger, a widely used functional food and food additive, little is known about the effect of ginger juice, which is rich in many healthful agents, on healthy humans or on its relationship with gut microbiota composition variation. The aim of this study was to investigate the changes in the gut microbial communities that occur following the supplementation of fresh ginger-derived juice in healthy adults and its potential associations with function. A crossover intervention study in which 123 healthy subjects (63 men and 60 women) consumed fresh ginger juice from . or sterile 0.9% sodium chloride was conducted. 16S rRNA sequencing analyses were applied to characterize gut microbiota variation. We found that ginger juice intervention increased the species number of intestinal flora. A decreased relative abundance of the Prevotella-to-Bacteroides ratio and pro-inflammatory and while a tendency toward an increased Firmicutes-to-Bacteroidetes ratio, Proteobacteria and anti-inflammatory were found. When we did not consider gender, we found differences in bacterial diversity both in community evenness and in richness caused by ginger intervention. In fact, there were different changes in bacterial α-diversity induced by the ginger juice in men and women. We identified 19 bacterial genera with significant differences between the control group (women) and ginger group (women) and 15 significant differences between the control group (men) and ginger group (men) at the genus level. Our results showed that short-term intake of ginger juice had substantial effects on the composition and function of gut microbiota in healthy people. Moreover, our findings underscored the importance of analyzing both male and female individuals to investigate the effects of ginger on gut microbiota. Additional studies are necessary to confirm these findings.
生姜是一种广泛使用的功能性食品和食品添加剂，但对于富含多种有益成分的姜汁对健康人的影响及其与肠道微生物群组成变化的关系，我们知之甚少。本研究的目的是调查健康成年人补充新鲜生姜汁后肠道微生物群落的变化及其与功能的潜在关联。我们进行了一项交叉干预研究，123名健康受试者（63名男性和60名女性）饮用了新鲜生姜汁或无菌0.9%氯化钠溶液。应用16S rRNA测序分析来表征肠道微生物群的变化。我们发现，姜汁干预增加了肠道菌群的种类数量。普雷沃氏菌与拟杆菌的相对丰度降低，促炎的[具体物质1]和[具体物质2]减少，而厚壁菌与拟杆菌的比例、变形菌和抗炎的[具体物质3]有增加的趋势。当我们不考虑性别时，发现姜汁干预导致细菌多样性在群落均匀度和丰富度方面存在差异。事实上，姜汁对男性和女性细菌α多样性的影响存在不同变化。在属水平上，我们确定对照组（女性）和姜汁组（女性）之间有19个细菌属存在显著差异，对照组（男性）和姜汁组（男性）之间有15个显著差异。我们的结果表明，短期摄入姜汁对健康人的肠道微生物群组成和功能有显著影响。此外，我们的研究结果强调了分析男性和女性个体以研究生姜对肠道微生物群影响的重要性。需要进一步的研究来证实这些发现。
